Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. [5] [6] Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel [7] and a bicarbonate channel. [8] additionally Anoctamin-1 is apical iodide channel.

This review discusses the topology, electrophysiological properties, modulators and functions of TMEM16A in mediates nociception, gastrointestinal dysfunction, hypertension, and cancer and focuses on multiple regulatory mechanisms regarding TMEM16A.

2022年5月19日 · TMEM16A, a calcium-activated chloride channel involved in multiple cellular processes, is a proposed target for diseases such as hypertension, asthma, and cystic fibrosis. Despite these...

2017年12月13日 · Here we present de novo atomic structures of the transmembrane domains of mouse TMEM16A in nanodiscs and in lauryl maltose neopentyl glycol as determined by single-particle electron...

2017年12月1日 · 近年来，tmem16a在病理生理学中的作用及其在疾病治疗中的药靶地位受到高度重视。 本文对TMEM16A研究的最新进展进行综述。 钙激活氯通道(calcium-activated chloride channels, CaCCs)是一类在多种细胞中广泛表达的氯离子通道，介导一系列重要的生理功能。

2022年9月1日 · The Ca 2+ -gated Cl − channel TMEM16A is a key regulator of vital physiological functions such as control of vascular tone and local blood flow, and epithelial solute transport. The channel has emerged as a potential target for diseases such …

Arterial tone and capillary diameter can be controlled with TMEM16A modulators, highlighting TMEM16A as a target for disorders with a vascular component, including hypertension, stroke, Alzheimer's disease and vascular dementia.

TMEM16A(transmembrane protein 16A)于2008年被确认为CaCCs的分子身份之一。TMEM16A在多种病理生理过程中发挥重要的作用,如卵母细胞多重受精、分泌上皮细胞的液体分泌、平滑肌收缩、神经元兴奋、膜电位调节、感官信号传导以及肿瘤的发生和细胞迁移。

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over decades, TMEM16A over-expression and contribution to prognosis have been widely studied for multiple cancers strengthening the idea that TMEM16A could be a valuable biomarker and a promising therapeutic target.

2024年7月1日 · TMEM16A interacts with the phosphorylation-gated Cl − channel cystic fibrosis transmembrane conductance regulator (CFTR) in Xenopus oocytes, pulmonary artery endothelium, salivary glands, and airway epithelium. When TMEM16A expression is inhibited, CFTR Cl − currents are absent [188].