TLR4 is the mammalian receptor recognizing bacterial lipopolysaccharide (LPS), the main cell wall component of Gram-negative bacteria, and plays a critical role in sepsis and controlling bacterial infections [24]. The molecular basis of how TLR4 mediates activation of RAS-GTPase upstream to MEK is not precisely understood.

2025年2月14日 · We demonstrated that autophagy activation can be attributed to increased expression of high-mobility group box 1 (HMGB1); co-inhibition of two HMGB1 receptors, receptor for advanced glycosylation...

Tyrosine kinase phosphorylation plays an important role in inflammatory mechanism, such as TLR4 tyrosine phosphorylation, MAPK pathway protein activation, and activation of downstream NF-кB. However, the effects of sorafenib on LPS-induced inflammatory reaction and its specific mechanism have still remained unknown.

2024年8月22日 · TLR4 is a single-pass transmembrane protein whose structure and function as a pattern recognition receptor (PRR) are highly conserved in mammals. TLR4 can be located on the cell surface and/or within cytoplasmic vesicles. TLR4 participates in direct and indirect interactions with viruses and viral proteins to trigger antiviral responses.

2023年10月1日 · TLR4 has significant meaning in the occurrence and development of cardiovascular and cerebrovascular diseases. TLR4 plays an important role in the occurrence and development of tumors through the immune system. TLR4 has two signaling pathways: MyD88 dependent and MyD88 independent.

2007年5月25日 · We demonstrated that pathogens trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1, which subsequently leads to acetylation of the NF-κB subunit p65, but only after TLR-induced activation of NF-κB. Acetylation of p65 both prolonged and increased IL10 transcription to enhance anti-inflammatory cytokine responses.

2023年10月16日 · Our data strongly suggest that SARS-CoV-2 interacts with the C-type lectin receptor DC-SIGN leading to Raf-1-mediated suppression of TLR4 signaling. We observed suppression of both type I IFN and cytokine responses and these inflammatory mediators are crucial in the defense against bacterial infections [ 33 , 34 ].

对肠道微生物群丰度及其与结肠炎参数的相关性的分析表明，Raf 部分缓解了 DSS 引起的生态失调。 总之，Raf 通过调节肠道微生物群和 TLR4-MyD88-NF-κB 通路对结肠炎发挥保护作用。

2018年9月1日 · Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice Nutrients . 2018 Sep 1;10(9):1208. doi: 10.3390/nu10091208.

结论 rab26对tlr4所介导的ards炎性因子表达，以及激活下游信号通路有抑制作用，为将来急性肺损伤诊治的方向和重点进一步提供了研究依据。 Author admin Posted on December 11, 2023