2009年1月21日 · Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common 'pattern' in structurally diverse LPS molecules. To …

2012年7月23日 · Toll-like receptor 4 (TLR4) and its coreceptor MD-2 recognize bacterial lipopolysaccharide (LPS) and signal the innate immune response. Two single nucleotide …

2007年7月22日 · TLR4 is an atypical member of the LRR family and is composed of N-terminal, central, and C-terminal domains. The beta sheet of the central domain shows unusually small …

" MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42 (Database issue):D297-303.

To date, 12 solution structures of human TLR4 are available in the Protein Data Bank (PDB) and are listed in Table 1. Most of the crystal structures are those of the ECD N terminus, only one...

Title: Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS. PDB DOI: https://doi.org/10.2210/pdb4g8a/pdb. Primary publication DOI: …

header immune system 21-jan-09 3fxi title crystal structure of the human tlr4-human md-2-e.coli lps ra complex caveat 3fxi pa1 e 2 has wrong chirality at atom c1 compnd mol_id: 1; compnd 2 …

2017年3月8日 · Toll-like receptor 4 (TLR4), a vital innate immune receptor present on cell surfaces, initiates a signaling cascade during danger and bacterial intrusion. TLR4 needs to …

In this review, we provide a brief overview of the biochemical evidences for possible pharmacologic applications of TLR4 ligands as therapeutics and report our systematic studies …

2012年11月23日 · Toll-like receptor 4 (TLR4) and its coreceptor MD-2 recognize bacterial lipopolysaccharide (LPS) and signal the innate immune response. Two single nucleotide …