The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR …

2013年12月6日 · Overview of LPS recognition by TLR4–MD-2. LPS binding induces dimerization of the TLR4–MD-2 complex, which is proposed to enable dimerization of the intracellular TIR domains and...

2025年3月18日 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe inflammatory diseases. Lipopolysaccharide (LPS), a pivotal pathogen-associated molecular pattern (PAMP) on the surface of gram-negative bacteria, is recognized by Toll-like receptor 4 (TLR4), initiating a complex cascade of immune ...

研 究显示，TLR4 能通过直接识别包括 LPS，脂磷壁酸（lipoteichoic acid，LTA），dsRNA 等在内的 病原相关分子模式 （pathogen associated molecular pattern，PAMP）而在激 活天然免疫过程中起到关键作用。近年来，该分子在引起炎症反应，抗病毒感染， 肿瘤治疗和调节免疫应答 ...

TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling cascades: the first one involving TIRAP and MyD88 adaptor proteins is induced in the plasma membrane, whereas the second engaging adaptor proteins TRAM and TRIF begins in early endosomes after endocytosis of the receptor.

1999年4月16日 · TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide in mammals.

在类toll受体中，tlr4是主要的脂多糖(lps)受体，并且tlr4被lps激活。 MyD88-和TRIF-依赖的信号通路被连续触发，并偶联LPS激活的TLR4从质膜到胞内体重新分配。

2016年10月1日 · Within a matter of weeks, Shizuo Akira’s group (6) confirmed that TLR4 was indeed the receptor for LPS and demonstrated this conclusively using functional and genetic studies. This paper is the focus of this installment of the Pillars of Immunology series.

Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling cascades: the first one involving TIRAP and MyD88 ad …

2009年3月1日 · Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common ‘pattern’ in structurally diverse LPS molecules. To understand the ligand...