NLRP3、NF-κB p65、TLR4与IL-1β信号通路的协同调控机制
2025年2月6日 · TLR4（Toll样受体4）是模式识别受体（PRRs）家族的重要成员，在先天免疫系统中起着关键作用。 它能够识别病原体相关分子模式（PAMPs），如脂多糖（LPS）等，并触 …
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses ...
2011年1月15日 · To define the contribution of gp130 signaling events to TLR4-driven inflammatory responses, we combined genetic and therapeutic approaches based on a series …
深入解析NLRP3、NF-κB P65、TLR4与IL-1β信号通路的相互作用机制
2024年12月30日 · TLR4（Toll样受体4）是Toll样受体家族中的重要成员，主要作为脂多糖（LPS）的受体，在识别并响应细菌等微生物成分的过程中发挥着关键作用。 当LPS与TLR4 …
靶点解惑Plus | NLRP3/NF-Kb P65/TLR4/IL-β信号通路详解！6个真 …
il-1ri可结合il-1α和il-1β，以及白细胞介素1受体拮抗剂il-1ra。 后者是一种天然存在的IL-1信号传导抑制剂。 IL-1的结合诱导IL-1RI的构象发生变化，然后IL-1RI再与IL-1受体辅助蛋白(IL-1RAcP) …
Toll-like receptor 4: A potential therapeutic target for multiple …
2023年10月1日 · The interplay between Aβ, Toll-like receptor 4 (TLR4), NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, and interleukin-1β (IL-1β) within microglia …
TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA ... - PubMed
2017年3月17日 · Here, we found that during the early phase of lipopolysaccharide (LPS) stimulation, NF-κB and an NF-κB-triggered IL-6-positive feedback loop activate Arid5a gene …
TLR4 Activation Is Required for IL-17–Induced Multiple Tissue ...
2010年8月15日 · Our results suggest that IL-17 may induce disease-associated tissue inflammation and wasting through TLR4 signaling. The study indicates a novel interaction …
Role of toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6 ...
2018年5月29日 · Indirect IL-6 production is mediated through innate immune receptor, Toll-like receptor 4 (TLR4). TLR4 is expressed on glial, immune and intestinal epithelial cells with …
TLR4 activation is required for IL-17-induced multiple tissue ...
2010年8月15日 · Our results suggest that IL-17 may induce disease-associated tissue inflammation and wasting through TLR4 signaling. The study indicates a novel interaction …
Toll-like receptor 4 (TLR4) inhibitors: Current research and ...
2022年5月5日 · Toll-like receptor 4 (TLR4) could mediate inflammatory response by triggering the production of various proinflammatorymediators, which are associated with sepsis, …