LPS promotes phosphorylation at both tyrosine residues, with Y749 phosphorylation being required for maintenance of total TLR4 protein levels and Y672 phosphorylation exerting its pro-inflammatory effects more selectively by initiating ERK1/2 and c-FOS phosphorylation.

结果表明：白头翁汤可以显著降低LPS诱导的TLR4、TRAF6、ERK的mRNA水平及蛋白表达并降低了LPS诱导的细胞下游炎性因子的分泌。 白头翁汤通过抑制TLR4-ERK1/2信号通路缓解LPS所诱导的RIMVECs炎性反应，发挥抗炎作用。 Abstract: In recent years, the researches on the anti-inflammatory mechanisms of Traditional Chinese Medicine formula have been in-depth.

2023年4月14日 · LPS promotes phosphorylation at both tyrosine residues, with Y749 phosphorylation being required for maintenance of total TLR4 protein levels and Y672 phosphorylation exerting its pro-inflammatory effects more selectively by initiating ERK1/2 and c-FOS phosphorylation.

In this commentary, we address new insights gained in recent years and comment on emerging work using a genetic approach to address the role of MEK1 in TLR4 mediated signaling as well as possible alternative pathways that lead to ERK activation in macrophages independent of MEK1.

2019年6月21日 · We provide the first direct evidence that S100a8/a9 (an inflammatory molecule) causes mitochondrial dysfunction via suppression of Toll-like receptor 4 (TLR4)/Erk-mediated Pparg coactivator 1 alpha (PGC-1α)/ nuclear respiratory factor 1 (NRF1) signaling, subsequent to mitochondrial complex I inhibition.

2015年8月31日 · We propose a novel pathway in which TLR2 and TLR4 induce IRAK1-ERK activation, which subsequently regulates the ERK–p67phox interaction and Nox-2-dependent ROS generation for IL-1β ...

lps 促进两个酪氨酸残基的磷酸化，其中 y749 磷酸化是维持总 tlr4 蛋白水平所必需的，而 y672 磷酸化则通过启动 erk1/2 和 c-fos 磷酸化来更有选择性地发挥其促炎作用。

2017年12月3日 · 本实验以 CAV-1 在高氧炎症反应中对TLR4/ERK/NF- B 信号通路的影响为研究对象，探讨其在高氧肺损伤发病机制中的作用。 方法 采用 cav1 基因敲除（KO）小鼠来研究高氧导致的肺损伤 CAV-1 表型，建立了野生型小鼠（wild type mice, WT）和 cavl 基因消除（cav1 gene knockout mice, cavl KO）小鼠高氧暴露动物模型；采用 ELISA 的方法对 WT 和 cav1 KO 小鼠炎症因子表达（IL-6 和 ... VII 中文摘要 目的 虽然高氧已广泛应用于 ICU 患者的临床治疗，但活性 …

2021年11月4日 · 2021年3月俄亥俄州立大学医学中心Allan Tsung教授和Hai Huang教授在《Cancer Research》上发表了题为《Platelet TLR4-ERK5 axis facilitates NETs-mediated capturing of circulating tumor cells and distant metastasis after surgical stress》的论著。 论文细致地描述了血小板TLR4-ERK5轴在促进中性粒细胞胞外诱捕网（NETs）介导的循环肿瘤细胞捕获中发挥的作用，并提出靶向血小板活化通路TLR4/ERK5/integrin GPPIIb/IIIa具有防止术后NETs介导的肿 …

Toll‑like receptor 4 (TLR4) is a pivotal component of the innate and adaptive immune response during infection and inflammation. Programmed‑death ligand 1 (PD‑L1) is hypothesized as an important factor for non‑small cell lung cancer (NSCLC) immune escape.