2020年2月18日 · Here we found that picomolar concentrations of soluble oligomers of synthetic beta amyloid (Aβ42) aggregates incubated with BV2 cells or rat astrocytes caused a sensitised response of Toll-like...

Interestingly, curcumin attenuated the activation of TLR4/NF-κB pathways and the downregulation of TREM2 expression in LPS-activated BV2 cells. Collectively, these results suggest that curcumin significantly alleviates LPS-induced inflammation by regulating microglial (M1/M2) polarization by reducing the imbalance of TREM2 and TLR4 and ...

2020年8月10日 · Our results showed that TLR4 was activated following SCI and promoted the expression of lncRNA-F630028O10Rik. This lncRNA functioned as a ceRNA for miR-1231-5p/Col1a1 axis and enhanced microglial...

2024年8月18日 · 本研究结果显示，lps诱导的bv2细胞中il-1β、tnf-α和il-6促炎因子水平显著提高，同时提高了tlr4、myd88蛋白表达水平和p65、iκbα的磷酸化水平；而lin的干预显著逆转促炎因子和这些蛋白的高表达水平。

2023年6月1日 · In our study, ACR stimulation only increased TLR2 and TLR4 levels in BV2 cells, indicating that ACR may activate TLR2 and TLR4. To fully prove our hypothesis that is TLRs-initiated LRRK2-NFATc2 activation, LRRK2 expression was measured in BV2 cells with TLR2 inhibitor TLR2-IN-C29 and TLR4 blocker Resatorvid pretreatment, respectively.

实验结果表明，lps刺激bv2细胞后tlr4、nf-κb的转录水平、ikb-α蛋白的磷酸化水平均显著上升；同时促进了bv2细胞nf-κb p65核转位，激活nf-κb下游炎症通路。

2024年12月15日 · Formononetin can block the apoptosis and inflammation of BV2 microglia induced by OGD/R by inhibiting TLR4/NF-κB signaling pathway. Ischemic stroke, caused by diminished or interrupted cerebral blood flow, triggers the activation of microglial cells and subsequent inflammatory responses.

2019年12月1日 · Therefore, we investigated whether the activation of TREM2 via TLR4/NF-κB suppression confers neuroprotective effects against LPS-induced neuroinflammatory responses in BV2 cells. As expected, the results demonstrated that LPS effectively enhanced the expression of TLR4, the degradation and phosphorylation of IκBα, and the phosphorylation of ...

TLR4 signalling plays a critical role in the activation of BV-2 cells and the induction of inflammation in this cell model. MPP (+) incubation at the concentration of 0.1 mM for 12 hours is the best condition to activate BV-2 cells for mimicking PD inflammation in BV-2 cells.

目的:运用脂多糖(Lipopolysaccharide,LPS)诱导BV2小胶质细胞建立神经炎症反应模型,探讨富血小板血浆(Platelet-Rich Plasma,PRP)对BV2小胶质细胞中枢神经炎症的抗炎作用及其相关机制,为下一步更深入的机制研究及今后的临床使用提供理论依据.方法:通过二次离心法制备富 ...