TLR10 is the only known member of TLR family that can elicit anti-inflammatory effect. TLR10 can inhibit other TLRs by competing with stimulatory TLRs, dimerising with TLR1, TLR2 and TLR6, and by inducing PI3K/Akt to produce IL-1Ra.

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene. [3] TLR10 has also been designated as CD290 (cluster of differentiation 290). TLR10 has not been extensively studied because it is a pseudogene in mice, though all other mammalian species

Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10.

TLR是一类定位在膜上的模式识别受体，在人类中具有10种（TLR1-TLR10）在小鼠中具有12种（TLR1-TLR9，TLR11-TLR13）。 该家族蛋白均为糖蛋白，N端为朝向胞外（或endosome腔内）具有底物结合能力的Leucine-rich repeat（LRR），而另一侧则是负责将信号转导入胞内的Toll/interleukin-1 (IL-1) receptor homology (TIR)结构域（图1）。 1996年，Jules A. Hoffmann实验室发现Toll信号通路在果蝇成虫中控制抗真菌感染中至关重要的果蝇霉素（drosomycin）的表 …

2020年10月12日 · Polymorphisms in the TLR10 gene can change the balance between pro- and anti-inflammatory responses and hence modulate the susceptibility to infection and autoimmune diseases. Understanding the full range of TLR10 ligands and functions may allow the receptor to be exploited as a therapeutic target in inflammation- or immune-related diseases.

2025年3月30日 · TLR10 (Toll Like Receptor 10) is a Protein Coding gene. Diseases associated with TLR10 include Melioidosis and Inflammatory Bowel Disease 20. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-Like receptor Signaling Pathways.

2025年2月8日 · TLR10 is a modulatory pattern-recognition receptor with mainly inhibitory properties; Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. CCL20, CCL1, & IL-8 were reduced following TKR10 knockdown. TLR10 silencing increased viability of L. monocytogenes in both HT-29 & THP-1 cells.

Understanding the full range of TLR10 ligands and functions may allow the receptor to be exploited as a therapeutic target in inflammation- or immune-related diseases. Here, we summarize recent findings on the pro- and anti-inflammatory roles of TLR10 and the molecular pathways in which it is implicated.

2014年10月6日 · We demonstrate the biological role of TLR10, the only member of the Toll-like receptor (TLR)-family so far without a known function. We show that TLR10 acts as an inhibitory receptor, with suppressive effects. Blocking TLR10 by specific antibodies significantly upregulated TLR2-mediated cytokine production.

该基因编码的蛋白质是 Toll 样受体 (TLR) 家族的成员，该家族在病原体识别和先天免疫激活中起着重要作用。 TLR 从果蝇到人类高度保守，并具有结构和功能相似性。 它们识别在传染原上表达的病原体相关分子模式 (PAMP) ，并介导产生有效免疫力所必需的细胞因子。 各种 TLR 表现出不同的表达模式。 该基因在淋巴组织如脾脏、淋巴结、胸腺和扁桃体中表达最高。 已针对该基因发现了编码不同蛋白质亚型的多个选择性剪接转录物变体。 [RefSeq 提供，2010 年 8 月]