TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC …
2017年7月1日 · Induction of proinflammatory T cell immunity is augmented by innate dendritic cell (DC) maturation commonly initiated by TLR signaling. We demonstrate that ligation of TLR3, …
下一代疫苗佐剂： TLR激动剂 - 知乎 - 知乎专栏
2023年9月12日 · dc细胞的tlr在自我/非自我抗原识别以及是产生免疫反应还是免疫耐受中起着关键作用。不同类型的apc表达不同的tlr，例如 髓系dc 表达tlr2和tlr4，而 浆细胞样dc （pdc）表 …
Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and …
Numerous TLRs 2, 3, 4, 7, 8, and 9 have been identified as molecules of interest for the development of agonist, antagonist, and vaccines to develop a treatment strategy to control …
TLR2免疫调节作用的研究进展 - 现代免疫学
TLR2是PRR中TLR家族成员之一，可识别PAMP，以及损伤相关分子模式（damage-associated molecular pattern， DAMP）。 在机体免疫微环境中，TLR2信号通路能够影响DC、巨噬细胞 …
Toll-like receptor 2 (TLR2) and TLR4 are present inside human …
We show here that TLR2 and TLR4 are expressed inside DCs in an abundant tubulovesicular pattern with a focus of intense staining adjacent to the nucleus. In contrast, there was no …
Selected Toll-like receptor agonist combinations ... - Nature
2005年7月3日 · In human and mouse DCs, TLR3 and TLR4 potently acted in synergy with TLR7, TLR8 and TLR9 in the induction of a selected set of genes. Synergic TLR stimulation …
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity
IFN-γ combined with TLR ligation TLR2, TLR4, or TLR9 agonists can enhance DC activation and function to increase antigen-specific T cell responses . Interestingly, TLR2 seems more critical …
Toll样受体及与树突状细胞的分化和信号转导的研究进展
tlr-2，tlr-4是研究较为清楚的感染受体，他们表达于dc，识别病原相关分子模式，刺激dc，通过胞内信号转导，或直接触杀，或诱生细胞因子和化学激活因子扩大非特异防御作用，或提供共刺 …
TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC …
2017年7月1日 · Induction of proinflammatory T cell immunity is augmented by innate dendritic cell (DC) maturation commonly initiated by TLR signaling. We demonstrate that ligation of TLR3, …
Human Dendritic Cell DC-SIGN and TLR-2 Mediate …
2015年3月27日 · DC-SIGN was required for Lb. rhamnosus JB-1 adhesion and influenced IL-12 secretion, while TLR-2 influenced IL-10 and IL-12 secretion. Here we demonstrate that the …