cGAS-STING 信号通路发现史（上） - 知乎专栏
在STING发现以前，大量的研究已经表明两类重要的转录因子（transcription factors），一个是NF-kB，另一个是IRF3，这两个转录因子都能在病毒入侵时诱导一系列基因表达谱发生改变以产 …
IRFs: master regulators of signalling by Toll-like receptors and ...
2006年9月1日 · In this section, we summarize recent findings relating to the activation mechanisms and functions of IRFs in TLR signalling. IRF3 and IRF7: activation by ligation of …
IRF3 mediates a TLR3/TLR4-specific antiviral gene program
Selective activation of the TLR3/TLR4-IRF3 pathway potently inhibited viral replication. These results suggest that TLR3 and TLR4 have evolutionarily diverged from other TLRs to activate …
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in ...
Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)-domain-containing adaptor-inducing …
TLR signalling and activation of IRFs: revisiting old friends …
2005年9月1日 · TLR3 interacts directly with TRIF to trigger these Myd88-independent pathways. In addition, TLR3 interacts with PI3K and activates Akt, leading to further phosphorylation and …
IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program - Cell …
2002年2月25日 · The specific activation of IRF3 by TLR3 and TLR4 led us to investigate gene expression with extensive titration of TLR-agonists. We found that increasing doses of PGN …
IKKε and TBK1 are essential components of the IRF3 signaling
2003年4月14日 · To investigate how signals are transmitted from TLRs to IKKε and TBK1, we examined the effect of the TLR adapter proteins MyD88, Mal and TRIF 13,17,20,22,37 on the …
IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB
2018年4月26日 · Our findings indicate that IRF3 negatively regulates TLR-mediated NF-κB signaling pathway by targeting TRIF for ubiquitination and degradation. This study provides a …
A high throughput screening for TLR3-IRF3 signaling pathway …
2010年5月5日 · Toll-like Receptor 3 (TLR3) is one of the major innate immune sensors of double stranded RNA (dsRNA). The signal transduction pathway activated by TLR3, upon binding to …
The multiple roles of interferon regulatory factor family in health …
2024年10月9日 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, …