Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-spanning receptors usually expressed on sentinel cells such as macrophages …

TLR signaling can prime cells for an enhanced responsiveness to stimuli that drive the assembly and activity of inflammasomes. Simultaneous exposure of cells to TLR ligands and stimuli that …

Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen …

2020年3月19日 · Herein, we describe the mechanisms and consequences of TLR-mediated signal transduction with a focus on themes identified in the TLR pathways that also explain the …

2024年4月9日 · Understanding the delicate balance between TLR activation and regulatory mechanisms is crucial for deciphering their dual role in immune defense and disease …

TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR …

2006年1月20日 · TLRs recognize specific molecular patterns found in a broad range of microbial pathogens such as bacteria and viruses, triggering inflammatory and antiviral responses and …

Toll 样受体 (TLRs) 可识别不同的病原体相关分子模式，并在先天性免疫应答中扮演着不可或缺的角色。 它们是抵御病原体入侵的第一道防线，在炎症、免疫细胞调控、存活和增殖方面发挥 …

2019年12月12日 · Toll-like receptors (TLRs) are an important family of receptors that constitute the first line of defense system against microbes. They can recognize both invading pathogens …

2025年2月17日 · TLR activation occurs when a ligand binds the receptor's LRR domain, transmitting a signal to the cell's cytoplasm. 9 TLRs have several adaptor molecules attached …