Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. [5] It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. [6]

2024年1月22日 · 功能：tlr5的主要功能是通过识别细菌鞭毛蛋白来参与免疫防御机制，它的激活可以触发多种免疫应答，包括抗原识别： tlr5能够识别和结合细菌鞭毛蛋白，这是细菌用于运动的结构性蛋白，特别是在革兰氏阴性细菌中普遍存在。

根据染色体的位置、 基因结构 和 氨基酸 序列，人的TLRs受体可以分为5个 亚科，即 TLR2， TLR3， TLR4，TLR5和TLR9。 TLR2亚科有TLR1， TLR2， TLR6和TLR10；TLR9亚科有TLR7， TLR8和TLR9；TLR3，TLR4和TLR5各自形成一个亚科。 TLRs分布的细胞多达20余种，Muzio M 等对TLR1-TLR5表达于人类 白细胞 的研究中发现，TLR1能在包括 单核细胞， 多形核 细胞，T、 B淋巴细胞 及 NK细胞 等多种细胞中表达，TLR2、TLR4、TLR5只在髓源性细胞 ( …

该基因编码 toll 样受体 (TLR) 家族的一个成员，该家族在病原体识别和先天免疫反应的激活中起着重要作用。 这些受体识别在感染因子上表达的不同病原体相关分子模式。 由该基因编码的蛋白质识别细菌鞭毛蛋白，细菌鞭毛的主要成分和毒力因子。 该受体的激活动员了核因子 NF-kappaB，后者又激活了许多与炎症相关的靶基因。 该基因的突变与对系统性红斑狼疮的抵抗力和易感性以及对军团病的易感性有关。 [RefSeq 提供，2009 年 12 月]

2025年3月30日 · TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Legionnaire Disease and Melioidosis. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity.

2017年11月20日 · TLR5 is known to specifically sense and recognize flagellin, the major structural protein of bacterial flagella. 2 It is conceivable that the immune system is equipped with TLR5 for the...

Epub 2017 Nov 20. 1 Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.

2017年4月5日 · Toll-like receptor 5 is a type-I transmembrane glycoprotein consisting of three domains, extracellular hydrophobic domain for ligand binding, transmembrane domain for homo- or heterotypic interaction that allows dimerization with same or different TLRs, and an intracellular cytosolic domain that consists of TIR domain for initiating downstream ...

Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation. Upregulation of TLR5 indicates a favorable prognosis in prostate cancer. Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation. Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5.