Role of TL1A in Inflammatory Autoimmune Diseases: A …
Here, this study summarized information about the molecular mechanism of TL1A and discussed role of TL1A in immune cells, especially focused on association between TL1A and …
Vascular endothelial growth inhibitor - Wikipedia
Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene.
Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for ...
Sep 25, 2024 · Tulisokibart is a tumor necrosis factor–like cytokine 1A (TL1A) monoclonal antibody in development for the treatment of moderately to severely active ulcerative colitis. A …
Role of TL1A in Inflammatory Autoimmune Diseases: A ... - PubMed
Jul 14, 2022 · TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and …
TL1A: A New Potential Target in the Treatment of Inflammatory Bowel ...
Recent studies showed that TL1A (Tumor necrosis factor-like cytokine 1A) acts as a regulator of mucosal immunity and participates in immunological pathways involved in the IBD …
TL1A, a novel alarmin in airway, intestinal, and autoimmune …
Feb 24, 2025 · TNF-like cytokine 1A (TL1A) is a member of the TNF cytokine superfamily, first identified in human endothelial cells. TL1A is now considered a novel alarmin expressed by …
The TNF-family cytokine TL1A: from lymphocyte costimulator to …
Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been found to …
TL1A: Exploring a potentially important target for inflammatory
Oct 9, 2024 · TL1A is a cytokine, a protein functioning as a chemical messenger, that acts as a regulator of cellular immunity. In healthy people, levels of TL1A increase to help immune cells …
TL1A/DR3 signaling regulates the generation of pathogenic Th9 …
2 days ago · Death receptor 3 (DR3) and its ligand, tumor necrosis factor-like ligand 1A (TL1A), regulates the balance between effector and regulatory T cells in IBD. While IL-9-secreting Th9 …
TL1A inhibition for inflammatory bowel disease treatment: From ...
May 10, 2024 · The pivotal role of TL1A in modulating immune pathways crucial for inflammatory bowel disease (IBD) and intestinal fibrosis offers a promising therapeutic target. Phase 2 trials …