Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans ...
2019年5月13日 · Here, we show that activation of Toll-like receptor 2 (TLR2) on primary human peripheral blood mononuclear cells (PBMCs) and on the monocytic cell line THP-1 induces …
IL-6 trans-signaling is another pathway to upregulate Osteopontin
IL-6 and sIL-6R induced by IL-1β may trigger IL-6 trans-signaling, contributing to the upregulation of OPN in THP-1 macrophages. Macrophages may be used as a source of IL-6 and sIL-6R …
Interleukin-6 controls recycling and degradation, but not ...
2020年12月10日 · In the present study, we show that the IL-6R and gp130 are internalized constitutively and independently of IL-6. Both receptors are internalized by clathrin-mediated …
IL-6 and IL-6 receptor modulation by IFN-gamma and tumor
1991年10月15日 · The present work is a detailed study of the mechanism of IFN-gamma- and TNF-alpha-triggered IL-6 secretion and IL-6 gene expression in human monocytic THP-1 cells …
PMA treated THP-1-derived-IL-6 promotes EMT of SW48
2018年12月1日 · In order to investigate the effect of macrophage and IL-6 on EMT of colon cancer, we cultured human colon carcinoma cell line SW48 with conditioned medium (CM) …
Shedding of Endogenous Interleukin-6 Receptor (IL-6R
2015年10月23日 · Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform …
Different Soluble Forms of the Interleukin-6 Family Signal …
2016年7月7日 · IL-6·sIL-6R complexes initiate IL-6 trans-signaling via activation of the ubiquitously expressed membrane-bound β-receptor glycoprotein 130 (gp130). Inhibition of IL …
MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression ...
2019年3月18日 · MCT-1 stimulated interleukin-6 (IL-6) secretion that promoted monocytic THP-1 polarization into M2-like macrophages to increase TNBC cell invasiveness. In addition, MCT-1 …
Shedding of the soluble IL-6 receptor is triggered by Ca2 ... - PubMed
The soluble IL-6 receptor (sIL-6R) is generated through either proteolytic shedding of the cognate receptor (PC-sIL-6R), or released as the product of differential mRNA splicing (DS-sIL-6R). …
Spontaneous cell surface expression of IL-6R by THP-1
Human osteoblasts produce interleukin-6 (IL-6) and respond to IL-6 in the presence of soluble IL-6 receptor (sIL-6R), but the cell surface expression of IL-6R and the mechanism of sIL-6R...
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