2025年3月30日 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are TGFBR2 Kinase Domain Mutants in Cancer and TGF-beta receptor signaling activates SMADs.

The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.

TGFBR2 forms an endocytic complex with PTH1R in response to PTH and regulates signalling by PTH and TGF-beta. TGFBR2 directly phosphorylates the PTH1R cytoplasmic domain, which modulates PTH-induced endocytosis of the PTH1R-TGFBR2 complex.

2024年9月8日 · Go to complete Gene record for TGFBR2; Go to Variation Viewer for TGFBR2 variants; Summary. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with …

HGNC Approved Gene Symbol: TGFBR2. Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38) : 3:30,606,356-30,694,142 (from NCBI) By screening a human hepatoma cell cDNA library with a porcine TGFBR2 cDNA as probe, Lin et al. (1992) isolated a TGFBR2 cDNA encoding a deduced 567-amino acid protein.

2025年2月9日 · Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties. Narushima Y, et al. Mol Cell Proteomics, 2016 Mar. PMID 26670566, Free PMC Article.

2021年4月29日 · Transforming growth factor β (TGFβ) signaling plays critical roles in reproductive development and function. TGFβ ligands signal through the TGFβ receptor type 2 (TGFBR2)/TGFBR1 complex.

2020年10月21日 · Here we show that depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4 + T cells, but not CD8 + T cells, halts cancer progression as a result of tissue healing and...

2025年1月30日 · Our comprehensive genetic analysis suggested that the p.Glu335_Tyr336delinsAsp variant of TGFBR2 caused aberrant TGF-β signaling and contributed to LDS in the patient.

2006年8月24日 · We found a mutation in TGFBR1 or TGFBR2 in all probands with typical Loeys–Dietz syndrome (type I) and in 12 probands presenting with vascular Ehlers–Danlos syndrome (Loeys–Dietz syndrome type...