2025年3月30日 · TFR2 (Transferrin Receptor 2) is a Protein Coding gene. Diseases associated with TFR2 include Hemochromatosis, Type 3 and Hemochromatosis, Type 1. Among its related pathways are Insulin receptor recycling and Transport of inorganic cations/anions and amino acids/oligopeptides.

2005年8月29日 · TFR2-related hemochromatosis (TFR2-HC) is characterized by increased intestinal iron absorption resulting in iron accumulation in the liver, heart, pancreas, and endocrine organs. Age of onset is earlier than in HFE-related hemochromatosis.

Human TfR2, another receptor for Tf, is predominantly expressed in hepatocytes and erythroid precursors, and holo-Tf dramatically upregulates its expression. TfR2 forms a complex with hemochromatosis protein, HFE, and serves as a component of the …

Transferrin receptor 2 (TfR2) is a homologue of transferrin receptor 1 (TfR1), the protein that delivers iron to cells through receptor-mediated endocytosis of diferric transferrin (Fe 2 Tf). TfR2 also binds Fe 2 Tf, but it seems to function primarily in …

The TFR2 gene provides instructions for making a protein called transferrin receptor 2. The main function of this protein is to help iron enter liver cells (hepatocytes).

2004年12月15日 · Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis. In this study, iron-responsive regulation of TfR2 at the protein level was examined in vitro and in vivo.

TfR2 is predicted to bind the iron carrier transferrin (Tf) when the iron-saturation of Tf is high. To better understand the nature of these TfR-Tf interactions, a binding study with the full-length receptors was conducted.

TfR2 can bind iron-loaded transferrin (Tf) in the bloodstream, and hepatocytes treated with Tf respond with a 2-fold increase in hepcidin expression through stimulation of the bone morphogenetic protein (BMP)-signaling pathway.

2001年9月15日 · In this paper, we describe the molecular cloning, chromosomal mapping, and characterization of expression of murine TfR2. Tissue distribution of TfR2 was clearly different from that of TfR1.

2024年8月17日 · TFR2 regulates ferroptosis and enhances temozolomide chemo-sensitization in gliomas. Tong S, Hong Y, Xu Y, Sun Q, Ye L, Cai J, Ye Z, Chen Q, Tian DTong S, et al . Exp Cell Res, 2023 Mar 1.