蛋白和抗体通过血脑屏障（BBB）的输送策略 - 知乎
受体介导的跨细胞转运 (RMT)和 载体介导的转运 (CMT)是BBB的主要内源性转运系统。 底物选择性CMT负责运送小分子营养物质，包括葡萄糖、氨基酸、激素、离子和维生素等。 RMT通过 …
Transferrin’ across the blood–brain barrier - Nature
2020年6月5日 · Delivery of protein therapies to the brain has proven difficult because of the need to cross the blood–brain barrier (BBB). Now, two recent papers from researchers at Denali …
Nature系列综述：跨越血脑屏障的生物大分子递送策略|药物|受体
2021年12月23日 · 血脑屏障 （Blood–Brain Barrier） 是一种大脑血管、细胞以及其它组成大脑组织之间的保护性屏障，能为大脑提供一种防御机制来抵御血液中的外来病原体和毒素等。 由 …
A shorter linker in the bispecific antibody RmAb158-scFv8D3
2024年12月23日 · Transferrin Receptor (TfR)-mediated transcytosis across the blood-brain barrier (BBB) enables the uptake of bispecific therapeutic antibodies into the brain. At …
Strategies for delivering therapeutics across the blood ... - Nature
2021年3月1日 · Here we review recent developments and challenges related to selected blood–brain barrier-crossing strategies — with a focus on non-invasive approaches such as …
Transferrin Receptor-Mediated Uptake at the Blood-Brain ... - PubMed
2019年2月4日 · The transferrin receptor (TfR) is highly expressed by brain capillary endothelial cells (BCECs) forming the blood-brain barrier (BBB) and is therefore considered as a potential …
Blood-brain barrier transport using a high affinity, brain-selective ...
We established a functional selection method to identify high affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB.
Enhanced delivery of antibodies across the blood-brain
2022年12月9日 · We designed bispecific antibodies containing transcytosis-enabling modules (TEMs) formed by a single-chain variable fragment (scFv) fusion recognizing TfR or CD98 for …
Age, dose, and binding to TfR on blood cells influence brain …
2023年5月11日 · At the BBB, TfR allows transferrin-bound iron to transcytose across the endothelial cells to the brain parenchyma. The TfR expression is especially high in the …
Engineering antibody and protein therapeutics to cross the …
TfR-based BBB-crossing antibody carriers are often used to deliver three types of cargos: enzymes, recombinant proteins, and therapeutic antibodies. In each category, we discuss …