2021年12月13日 · Normal T cell development in the thymus undergoes a major developmental checkpoint in which T cell receptor (TCR) signaling is involved.

Here we highlight these recent findings, focusing on the proximal TCR signaling molecules Zap70, Lck and LAT, to provide mechanistic models and insights into the exquisite sensitivity and …

The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically.

2020年5月21日 · In this review, we summarize current knowledge on the pathways that govern how the TCR complex transmits signals into cells and the roles of effector molecules that are …

2 天之前 · T Cell Receptor (TCR) activation promotes a number of signaling cascades that ultimately determine cell fate through regulating cytokine production, cell survival, proliferation, …

2018年5月22日 · Here, we review newly identified mechanisms for the regulation of TCR signalling and then discuss how the TCR signalling response is regulated to control two critical …

TCR signaling is initiated by the engagement of the TCR with the antigen-MHC complex, a crucial event in the adaptive immune response. Upon antigen recognition, conformational changes …

In this review, we analyzed TCR and CAR signaling starting from the engagement of the antigen and receptor to downstream signaling. We also reviewed the interaction between different cell …

2015年5月1日 · In this study, we assessed the role of TCR-mediated signal transduction in the suppressive function of Tregs. Our data suggest that TCR-mediated signals downstream of …

Dysregulation of TCR signaling can lead to the generation of various diseases, given its importance in executing different functions of T cell biology. Thus, defects in TCR signaling …