Structural understanding of T cell receptor triggering
2020年2月11日 · The TCR Cβ FG loop, involved in thymic selection and T cell development, 28,29 is presumed to regulate T cell signaling. The loop resembles a lever and might transfer …
The TCR Cβ FG Loop Regulates αβ T Cell Development1
2006年6月1日 · Collectively, our results show that the unique Cβ FG loop appendage primarily controls αβ T cell development through selection processes. The TCR is a multisubunit …
A TCR mechanotransduction signaling loop induces negative ... - Nature
2018年11月12日 · We suggest that the coupled trans–cis heterodimeric interactions form a mechanotransduction loop that reinforces negative-selection signaling that is distinct from …
Structural basis of assembly of the human T cell receptor ... - Nature
2019年8月28日 · In this study, we report a cryo-electron microscopy (cryo-EM) structure of a human TCR–CD3 complex in its unliganded state at 3.7 Å resolution. The structure reveals the …
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop
Here we report the structural mechanism of TCR crossreactivity with two distinct peptides from human pathogens. The structures show that a single TCR residue (CDR3α F95) makes the …
Non-Antigenic Modulation of Antigen Receptor (TCR) Cβ-FG Loop …
2023年5月26日 · In this study, the bona fide binding sites targeting the TCR-Cβ-FG loop that modulate TCR engagement in immune signalling provide a rational drug design for the …
The TCR C beta FG loop regulates alpha beta T cell development
2006年6月1日 · The TCRbeta chain constant domain contains an unusually elongated, solvent-exposed FG loop. This structural element forms one component of an alphabeta TCR cavity …
TCR-pMHC complex formation triggers CD3 dynamics - eLife
2023年6月23日 · In this study, we present an allosteric mechanism for T cell receptor (TCR) triggering upon binding a peptide-MHC complex (pMHC), in which a conformational change in …
The TCR C FG Loop Regulates T Cell Development,The Journal of ...
2006年5月18日 · The TCRβ chain constant domain contains an unusually elongated, solvent-exposed FG loop. This structural element forms one component of an αβ TCR cavity against …
Involvement of the TCR Cbeta FG loop in thymic selection and T …
2002年6月3日 · The asymmetric disposition of T cell receptor (TCR) Cbeta and Calpha ectodomains creates a cavity with a side-wall formed by the rigid Cbeta FG loop. To …
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