Recent insights of T cell receptor-mediated signaling pathways for …
2020年5月21日 · In addition, T cells exhibiting loss of DGKα and/or DGKζ show increased TCR-induced signaling, including Ras-MAP kinase/ERK kinase-ERK-AP-1, PKCθ-NF-κB, and …
T 细胞受体信号转导 | Cell Signaling Technology
t 细胞受体 (tcr) 激活可促进许多信号转导级联反应，通过调控细胞因子产物、细胞生存、增殖和分化来最终决定细胞命运。 TCR 激活的早期事件是由淋巴细胞蛋白质酪氨酸激酶 (Lck)，对 …
TCR信号调节 - 知乎 - 知乎专栏
t细胞在获得型免疫系统中扮演着重要角色，正常t细胞的发育主要发生在胸腺需要 tcr信号通路 的参与。在tcr介导下，对自身多肽mhc复合体有较高亲和力的胸腺细胞会走向凋亡，那些低亲和力 …
SMAD4, activated by the TCR-triggered MEK/ERK signaling …
2022年7月27日 · Biochemically, SMAD4 was directly phosphorylated by ERK at Ser 367 residue following TCR activation. Our study thus demonstrates a critical yet unexpected role of …
T cell receptor (TCR) signaling in health and disease
2021年12月13日 · Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental …
TCR ligand discrimination is enforced by competing ERK
2003年2月10日 · Functional discrimination between structurally similar self and foreign antigens is a main attribute of adaptive immunity. Here we describe two feedback mechanisms in...
New modes of ERK feedback regulation in T cell receptor signaling ...
2012年5月1日 · Competing positive and negative signaling feedback pathways play a critical role in tuning the sensitivity of T cell receptor (TCR) activation by selectively enhancing responses …
T-cell receptor ligation induces distinct signaling pathways in naïve ...
Here we show that T-cell receptor (TCR) stimulation induces distinct ERK and p38 phosphorylation patterns in naïve and antigen-experienced human T cells, and that these …
Sos1 regulates sustained TCR-mediated Erk activation
In T cells, sustained Erk activation correlates with differentiation/proliferation, whereas transient Erk activation parallels with unresponsiveness/apoptosis. The mechanism by which Son of …
TCR activation kinetics and feedback regulation in primary human …
2013年1月14日 · We demonstrate that sAbs activate negative feedback loops that terminate TCR-mediated signaling, whereas stimulation with iAbs results in the establishment of a positive …