In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

2019年8月28日 · Here we report a cryo-electron microscopy structure of human TCRαβ in complex with the CD3 hexamer at 3.7 Å resolution. The structure contains the complete extracellular domains and all the...

2020年4月19日 · TCR-CD3 complex majorly recognizes the Ag-MHC molecules and various other membrane molecule play important role in Ag recognition and T-cell activation. Some of these membrane molecules strengthen interaction between T cell and APC or target cells and some act in signal transduction and some do both.

2024年4月24日 · Here we report the structures of two prototypical human Vγ9Vδ2 and Vγ5Vδ1 TCR–CD3 complexes 5, 6, revealing two distinct assembly mechanisms that depend on Vγ usage. The Vγ9Vδ2 TCR–CD3 complex...

2021年12月13日 · The core TCR complex consists of two TCR chains and six cluster of differentiation 3 (CD3) chains. Several other components include coreceptors, kinases, and ligands. 14, 15 TCR-CD3 chains

2002年12月27日 · The T cell receptor-CD3 complex (TCR-CD3) serves a critical role in the differentiation, survival, and function of T cells, and receptor triggering elicits a complex set of biological responses that serve to protect the organism from infectious agents.

2020年1月24日 · We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR-CD3 complex, for dynamically-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of …

Signaling through the T cell receptor (TCR) controls key events in the life of T cells: their development in the thymus from common lymphoid progenitors, the survival of naïve T cells following their exit from the thymus, and the differentiation of these cells into effector populations with discrete functional profiles.

2024年11月7日 · Through crosslinking and docking, we identify a CD3ε′-CD3γ-CD3ε-CD3δ arrangement situated around the αβTCR in situ within the cell surface environment. We demonstrate the importance of cholesterol in maintaining the stability of the complex and that the ‘in situ’ complex structure mirrors the structure from ‘detergent-purified’ complexes.

The T cell receptor for antigen (TCR) consists of two glycoproteins containing variable regions (TCR-alpha/beta or TCR-gamma/delta) which are expressed on the cell surface in association with at least four invariant proteins (CD3-gamma, -delta, ...