T-cell receptor - Wikipedia
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major …
TCR和BCR是什么？对于疾病研究有何意义？ - 知乎专栏
T 细胞与 B 细胞表面上都存在受体分子，分别称为 T 细胞受体 （TCR）和 B 细胞受体 （BCR）。 T淋巴细胞（T cells）和B淋巴细胞（B cells）是负责适应性免疫应答的主要细胞，其抗原识别 …
Defining and studying B cell and T cell receptor interactions
B cell receptors (BCRs) and their secreted counterparts, antibodies, recognize native three-dimensional epitopes, whereas T cell receptors (TCRs) bind to linear peptide fragments from …
Spatial transcriptomics of B cell and T cell receptors reveals ...
We found spatial congruency between paired receptor chains, developed a computational framework to predict receptor pairs, and linked the expansion of distinct B cell clones to …
单细胞免疫组库测序-TCR & BCR - 知乎 - 知乎专栏
10X Genomics Single Cell Immune Profiling Solution是一种在单个细胞水平同时对转录组基因表达和适应性免疫受体库进行高通量测序的新技术，其基于10X Genomics平台，可以同时获 …
Single-cell immune repertoire analysis - Nature Methods
2024年4月18日 · Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on …
TCR - Cell Press
They identified a population of CD5 + cells expressing both a T cell receptor (TCR) and a B cell receptor (BCR) that they termed “double expresser” or DE cells. They documented increased …
T cell receptor (TCR) signaling in health and disease
2021年12月13日 · Initial studies demonstrated that T cells expressing common TCRα/TCRβ heterodimer with distinct functions—for example, cytotoxic T cells that directly destroy infected …
A Public BCR Present in a Unique Dual-Receptor-Expressing ... - Cell …
B and T cells are the two main lymphocytes of the adaptive immune system that work in concert to maintain host defense or cause autoimmunity in susceptible individuals. Expression of the B …
Defining and Studying B Cell Receptor and TCR Interactions
2023年8月1日 · Both the affinity and avidity of receptor binding play critical roles in cellular activation and differentiation, B cell selection, T cell tolerance, and Ab function. Avidity of …