Structural basis of assembly of the human T cell receptor–CD3 …
2019年8月28日 · In this study, we report a cryo-electron microscopy (cryo-EM) structure of a human TCR–CD3 complex in its unliganded state at 3.7 Å resolution. The structure reveals the …
Structures of human γδ T cell receptor–CD3 complex - Nature
2024年4月24日 · These findings reveal organizing principles of the γδ TCR–CD3 complex, providing insights into the unique properties of γδ TCR and facilitating immunotherapeutic …
T cell receptor (TCR) signaling in health and disease
2021年12月13日 · Signals from both the TCR-CD3 complex and co-stimulatory receptors, such as CD28, CD2, and the CD150/SLAM (signaling lymphocyte activation molecule) family, are …
Modulating T Cell Responses by Targeting CD3 - PMC
The TCR/CD3 complex determines the specificity of the immune response and is the first signal needed to trigger T cell activation. The development of new approaches to modulate the …
The structural basis of T-cell receptor (TCR) activation: An …
We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR–CD3 complex, for dynamically-driven TCR allostery, and for pMHC …
The structural basis of T-cell receptor (TCR) activation: An ... - PubMed
2020年1月24日 · We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR-CD3 complex, for dynamically-driven TCR …
Molecular mechanisms for the assembly of the T cell receptor–CD3 ...
The T cell receptor (TCR)–CD3 complex represents on of the most intricate membrane receptor structures since it is built from six distinct chains. This complexity led to a number of different …
Structural basis of assembly of the human T cell receptor-CD3 ... - PubMed
The αβ T cell receptor (TCR), in association with the CD3γε-CD3δε-CD3ζζ signalling hexamer, is the primary determinant of T cell development and activation, and of immune responses to …
Molecular architecture of the αβ T cell receptor–CD3 complex
2014年11月24日 · How antigen ligation by the TCR triggers CD3 activation and what structural role the CD3 extracellular domains (ECDs) play in the assembled TCR–CD3 complex remain …
T-cell receptor (TCR): structure, role and TCR-CD3 complex
2020年4月19日 · TCR-CD3 complex: The TCR complex is pictured as four dimers; αβ or Ƴ𝛿 of TCR and Ƴε, 𝛿ε and ζζ or ζη of CD3; The αβ or Ƴ𝛿 TCR heterodimer determines the ligand …
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