TCF4 is primarily involved in neurological development of the fetus during pregnancy by initiating neural differentiation by binding to DNA. It is found in the central nervous system, somites, and gonadal ridge during early development.

2025年3月30日 · TCF4 (Transcription Factor 4) is a Protein Coding gene. Diseases associated with TCF4 include Pitt-Hopkins Syndrome and Corneal Dystrophy, Fuchs Endothelial, 3. Among its related pathways are ERK Signaling and Signaling by TGFBR3.

2025年3月27日 · Background Transcription factor 4 (TCF4) is a member of the basic helix-loop-helix (bHLH) family of transcription factors that guides proper embryogenesis, particularly neurogenesis, myogenesis, heart development and hematopoiesis. The interaction of TCF4 with DNA is dependent on the presence of a conserved bHLH domain, particularly the presence of a basic (b) motif. Most mutations in the Tcf4 ...

TCF4 encodes a transcription factor containing a basic helix-loop-helix structural motif (bHLH). The proteins of this group contain a DNAbinding domain and can regulate gene expression, forming homo- and heterodimers.

tcf4是mes特征的核心调控因子，也是黑色素细胞和抗原递呈转录程序的抑制因子，是这一特征的枢纽，使用溴域抑制剂在基因上或药理学上靶向tcf4可增加mes细胞的免疫原性和对icb及靶向治疗的敏感性。

2024年1月4日 · Targeting TCF4 genetically or pharmacologically, using a bromodomain inhibitor, increased immunogenicity and sensitivity of MES cells to ICB and targeted therapy. We thereby uncovered a TCF4-dependent regulatory network that orchestrates multiple transcriptional programs and contributes to resistance to both targeted therapy and ICB in melanoma.

2021年1月5日 · The human transcription factor 4 gene (TCF4) encodes a helix–loop–helix transcription factor widely expressed throughout the body and during neural development.

This review focuses on the TCF4 gene that encodes a transcription factor crucial for nervous system development and functioning. Pathogenic variants in this gene have been linked to a rare genetic disorder, Pitt-Hopkins syndrome, and TCF4 polymorphic variants are associated with several socially significant diseases, including various ...

2025年2月8日 · TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019] Expression

编码的蛋白质识别 Ephrussi 盒 ('E-box') 结合位点 ('CANNTG') - 一个在免疫球蛋白增强剂中首次发现的基序。 该基因广泛表达，可能在神经系统发育中发挥重要作用。 该基因的缺陷是皮特-霍普金斯综合症的一个原因。 此外，通常编号为 10-37 个重复单元的内含子 CTG 重复可以扩展到 >50 个重复单元并导致 Fuchs 内皮角膜营养不良。 已经描述了编码不同蛋白质的多个选择性剪接的转录物变体。 [RefSeq 提供，2016 年 7 月] This gene encodes transcription factor 4, a basic …