Understanding how Tcf1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. This review discusses Tcf1, which plays context-dependent roles …

2021年10月6日 · The transcription factor TCF-1 has multiple roles during T cell development and in mature T cells. Gounari and Khazaie review the potential mechanisms by which TCF-1 …

2021年6月14日 · In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8 + T cells generated in response to viral or tumour antigens, and for preserving …

2021年8月12日 · Here, we show that TCF-1 primarily suppresses transcription of genes that are co-bound by Foxp3. Single-cell RNA-sequencing analysis identified effector memory T cells …

The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has …

Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. T cell factor 1 (TCF1, encoded by Tcf7) is the key transcription …

Mechanistically, we found that Tcf-1 directly binds and mediates chromatin accessibility for both typical T cell regulators and proto-oncogenes, including Myb, Mycn, Runx1, and Lyl1 in the …

2020年9月5日 · Here, we review the regulatory functions of TCF1 in the differentiation of T follicular helper cells, memory T cells and recently described stem-like exhausted T cells, …

2018年2月20日 · Our data in TCF-1 expressing fibroblasts led to two observations: (1) TCF-1 can generate chromatin accessibility at previously repressed domains and (2) TCF-1 can induce …

2021年7月15日 · Regnase-1 deficiency enhances CAR–T-cell persistence and CAR-T–mediated antitumor immunity in murine and human xenograft B-ALL models. Regnase-1 targets Tcf7 …

The T cell-specific DNA binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has …

The transcription factor TCF-1 is essential for the development and function of regulatory T (T reg) cells; however, its function is poorly understood. Here, we show that TCF-1 primarily …

Zheng et al. show that TCF-1 regulates the functions, but not the development, of LTi cells in different tissues. It is specifically required for optimal expression of lymphotoxin in LTi cells …

2022年6月20日 · The protein TCF-1 enables various parts of otherwise insulated DNA segments to intermingle in a way that is required for the development of T cells—a key element of the …

2019年12月1日 · Expression of TCF-1 is necessary for the development of ILC progenitor cells in mouse bone marrow. In murine T cell development, TCF-1 is critical for ETP development, …

TCF-1 drives the early wave of chromatin accessibility in T cell development. Tcf7 −/− mice cannot establish the open chromatin landscape of normal T cells. At the single-cell level, TCF …

Our results provide insight into the mechanisms by which TCF-1 promotes developmental progression of ILC precursors, while constraining their dendritic cell lineage potential and …

2021年4月29日 · Moreover, TCF-1 is a potential biomarker of CD8 + T cell functionality to predict the efficacy of immunotherapy in fighting against cancer and infections. Herein, we summarize …

TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of …

2019年10月16日 · TCF-1 plays a central role in this bifurcation by repressing T-bet and the development of terminal KLRG1+ effectors. TCF-1 also fostered Tex precursors by promoting …