Animal models of traumatic brain injury - Nature
2013年1月18日 · Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external mechanical force, such as that caused by rapid acceleration or...
Animal models of traumatic brain injury - PMC - PubMed Central …
Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external mechanical force, such as that caused by rapid acceleration or deceleration, blast waves, …
A novel simple traumatic brain injury mouse model - PMC
To meet the demand for a simpler and cost-effective device, herein we introduce a new TBI model via a rubber bullet impact without pre-injury manipulations on the skull bone. Male C57BL/6 …
Protocol for inducing varying TBI severity in a mouse model using …
2024年12月20日 · Here, we present a protocol to induce varying TBI severities in mice using a closed-head, weight-drop model that includes an impact-induced acceleration mechanism. We …
Traumatic brain injury using mouse models - PubMed
Mouse models provide powerful tools to screen for putative therapeutic targets in TBI. This article reviews currently available mouse models that replicate several clinical features of TBI such as …
High-altitude hypoxia aggravated neurological deficits in mice
2025年2月5日 · To reveal the cellular and molecular dynamics of TBI under high-altitude hypoxia, we collected brain tissues from the injured areas of the 2 groups of mice (LA_TBI and HA_TBI) …
Traumatic brain injury promotes neurogenesis at the cost of ...
2024年6月18日 · Using a controlled cortical impact model of TBI in male mice, single cell RNA sequencing and spatial transcriptomics, we assessed how TBI affected hippocampal NSCs …
Animal models of traumatic brain injury: a review of …
2021年7月29日 · Traumatic brain injury (TBI) is one of the main causes of death and disability in both civilian and military population. TBI may occur via a variety of etiologies, all of which …
Traumatic Brain Injury Using Mouse Models | Translational
2014年2月5日 · Mouse models provide powerful tools to screen for putative therapeutic targets in TBI. This article reviews currently available mouse models that replicate several clinical …
Mouse closed head traumatic brain injury replicates the …
2021年6月29日 · We conducted longitudinal histopathological characterization of a mouse closed head TBI model, with a focus on pathological features reported in human TBI-associated …