TAS2R38 是一种 苦味 味觉感受器 [1][2]，该感受器可以尝出 苯硫脲 [3] 和 丙硫氧嘧啶 [4] 或者相关物质的苦味。 这一点和大多数苦味感受器有所不同，即该感受器是对某类物质敏感，而大多数感受器则不会表现出强烈的选择性，能对多种物质做出响应 [5]。 该感受器所能尝出的相应物质大量存在于 西兰花 、 卷心菜 以及其它 十字花科 植物中 [5]，例如： 葡萄糖异硫氰酸盐 （英语：Glucosinolates） 及其相关产物 异硫氰酸酯。 目前全球人类中，约有75%该感受器相关基因 …

Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) [5] and phenylthiocarbamide (PTC).

2019年12月2日 · Here we evaluated the role of the bitter receptor TAS2R38 in attainment of longevity, since it has been widely associated with individual differences in taste perception, food preferences, diet,...

2016年5月3日 · Here we studied the distribution of TAS2R38 haplotypes in a large number of human populations and available archaic hominid genomes to provide a fine-scale view of worldwide TAS2R38 diversity,...

The human TAS2R38 gene encodes a bitter taste receptor that regulates the bitterness perception and differentiation of ingested nutritional/poisonous compounds in the oral cavity and gastrointestinal tract. TAS2R38 gene variants are associated with ...

2025年3月26日 · Title: Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA. Genetic variation in TAS2R38 bitterness receptor is associated with body composition in Korean females.

2025年3月30日 · TAS2R38 (Taste 2 Receptor Member 38) is a Protein Coding gene. Diseases associated with TAS2R38 include Thiourea Tasting and Dental Caries. Among its related pathways are GPCR downstream signalling and Sensory perception of taste.

该基因编码一个七次跨膜 G 蛋白偶联受体，该受体控制对芥子油苷的味觉能力，芥子油苷是一种在芸苔属植物中发现的苦味化合物家族。 合成化合物苯硫脲 (PTC) 和 6-正丙基硫氧嘧啶 (PROP) 已被确定为该受体的配体，并已用于测试该基因的遗传多样性。 尽管已在世界范围内鉴定出该基因的几种等位基因形式，但在非洲以外发现了两种主要的常见形式 (品尝者和非品尝者) 。 这些等位基因在三个核苷酸位置不同，导致蛋白质中的氨基酸发生变化 (A49P、A262V 和 V296I) ，氨基 …

TAS2R38 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (summary by Conte et al., 2002). For further information on the TAS2R gene family, see 604791.

2022年5月5日 · Bitter taste receptor TAS2R38 is expressed in the respiratory tract and can respond to quorum-sensing molecules produced by pathogens, stimulating the release of nitric oxide, with...