PNAS：突破！南京大学团队首次阐明了治疗哮喘和COPD的新靶 …
南京大学团队首次阐明了治疗哮喘和copd的新靶点——苦味受体的作用机制 苦味受体（tas2r）为g蛋白偶联受体（gpcr），除了感受味觉外，苦味受体还可以有效地…
Physiological activation of human and mouse bitter taste …
2023年6月7日 · To evaluate the agonistic efficacy of bile acids for human TAS2Rs, we compared the signal amplitudes of well-known TAS2R agonists with bile acids activating TAS2R1, …
Bitter taste TAS2R14 activation by intracellular tastants and ...
2024年5月22日 · Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents 1, …
重要突破！《科学》：首个苦味受体结构破解 - 知乎
研究人员使用 单颗粒冷冻电镜 技术，成功解析了 TAS2R46受体在马钱子碱激活（strychnine）及无配体（apo）两种状态下与下游G蛋白形成复合物的结构，首次揭示了苦味受体独特的三维 …
TAS2R38 bitter taste receptor and attainment of exceptional
2019年12月2日 · Here we evaluated the role of the bitter receptor TAS2R38 in attainment of longevity, since it has been widely associated with individual differences in taste perception, …
An update on extra-oral bitter taste receptors | Journal of ...
2021年10月21日 · Critical points of extra-oral TAS2Rs biology, such as their structure, roles, signaling transduction pathways, extensive mutational polymorphism, and molecular evolution, …
世界首次！揭开苦味受体的“神秘面纱” - ShanghaiTech
2022年9月16日 · 苦味受体（type 2 bitter taste receptor, TAS2Rs）是味觉系统中比较特殊的一类受体，与其它GPCR的序列同源性低，因此被单独归类为class T亚家族。 迄今，该受体家族 …
The molecular receptive ranges of human TAS2R bitter taste receptors
To address this issue, we have challenged 25 human taste 2 receptors (hTAS2Rs) with 104 natural or synthetic bitter chemicals in a heterologous expression system. Thirteen cognate …
Human intestinal bitter taste receptors regulate innate immune …
2022年2月1日 · Bitter taste receptors (taste 2 receptors, TAS2Rs) serve as warning sensors in the lingual system against the ingestion of potentially poisonous food. Here, we investigated …
细胞内味觉物质和胆固醇激活苦味受体TAS2R14 - 知乎
味觉受体（tasr）属于一组特殊的gpcr，可以解码甜味、鲜味和苦味。tas1r编码甜味和鲜味；tas2r编码苦味。tas2r14在味觉组织和口腔外组织中都有很多表达，例如心脏和呼吸道平滑 …