2024年11月13日 · 转化生长因子激酶1（TAK1），也被称为TGF-β-活化蛋白激酶1（Transforming Growth Factor-β-Activated Kinase 1）或有丝分裂原激活蛋白激酶激酶7（MAP3K7），是一种重要的信号传导蛋白激酶。

2021年1月4日 · Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes.

2021年1月5日 · Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding protein …

Here we demonstrate that TGF-β–activated kinase 1 (TAK1) works as a negative regulator of Fas signaling in macrophages. Upon Fas engagement with high concentrations of FasL, mouse primary macrophages underwent cell death, and, surprisingly, Fas stimulation led to proteolytic cleavage of gasdermin (GSDM) family members GSDMD and GSDME, a ...

2014年8月22日 · This review summarizes the consequences of TAK1 deficiency in different cell and tissue types from the perspective of cell death and also focuses on the mechanism by which TAK1 complex inhibits...

2025年3月1日 · The increasing incidence of inflammatory and malignant diseases signifies the need to develop first-in-class drugs with novel mechanisms of action. In this respect, the transforming growth factor (TGF)-β-activated kinase 1 (TAK1), an essential part of several signaling pathways, is considered relevant and promising.

转化生长因子-β激活激酶1（tak1）是nf-κb信号通路（如toll样受体和白介素1受体信号）激活过程中的关键激酶。尽管现有证据表明tak1的激活需要位于其活化环的第184位和第187位苏氨酸的磷酸化，但人们对tak1完全激活的分子机制仍缺乏深入了解。

2023年10月12日 · Transforming growth factor β–activated kinase 1 (TAK1), also known as mitogen-activated protein three kinases 7 (MAP3K7), is a member of the MAPKKK family serine/threonine kinases and functions as a signaling hub in innate immunity and pro-inflammatory signaling pathways. 46,47,48 TAK1 is activated by tumor necrosis factor alpha (TNF-α), IL-1β, ...

Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of …

转化生长因子-β（TGF-β）激活的激酶1（TAK1）是MAPK激酶激酶（MAPKKK）家族的成员，并已参与多种生理和病理过程的调控。 TAK1通过与其结合伴侣TAK1结合蛋白（TAB1，TAB2和TAB3）组装而发挥功能，并且可以被多种刺激物激活，例如肿瘤坏死因子α（TNFα），白介素-1β（IL-1β）和收费。 类受体配体，它们在NF-κB和MAPKs的激活中起重要作用。 大量研究表明，根据指示的细胞环境，翻译后修饰在正确控制TAK1-TAB复合物的活性，稳定性和装配中起 …