T98G [T98-G] is a fibroblast-like cell that was isolated from the brain of a glioblastoma multiforme White, 61-year-old, male patient. This cell line was deposited by GH Stein and can be used in neuroscience research.

人胶质母细胞瘤细胞t98g [t98-g]从一名罹患多形性胶质母细胞瘤的61 岁白人男性的脑肿瘤组织中分离获得，是一种永生化的成纤维细胞样的肿瘤细胞系。 据报道，该细胞在裸鼠体内不成瘤，核型为超五倍体（染色体众数128-132）。

T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.

T98G細胞是T98親本細胞系的多倍體變體，在穩態條件下可以停留在 細胞週期 中的 G1期 [1]。 目前已經研究了T98G細胞和A172細胞的藥物 細胞毒性 [3]，發現它們都對 順鉑 （一種 非特異性藥物）具有抗性，並且通過 病毒 介導的 p53 蛋白產生，具有更高的細胞毒性作用 [4]。 ^ 跳转到： 1.0 1.1 1.2 Stein, GH. T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro..

T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. J. Cell. Physiol. 99: 43-54, 1979. PubMed: 222778 Olopade OI, et al. Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas. Cancer Res. …

T98 G (human, Caucasian, glioblastoma) Continuous culture, grown as monolayer epithelial-like morphology SPECIES: human, Caucasian (male, 61 year old) Karyology: Hyperpentaploid; modal number 128-132 TUMOR: glioblastoma PROPERTIES: aging; proliferation studies. Available in the following LABORATORY: Russian Academy of Sciences (SPBIC, St ...

These cells possess fibroblast cells-like morphology. The glioblastoma cell line T98G represents hyperpentaploidy. The modal chromosome number varies between 128 to 132. Higher ploidies may exist in 1.39% of the cell population. T98 Vs T98G. Both are human glioblastoma cell lines and share a similar origin.

T98G细胞系在实验室条件下能够持续传代，并保持相对的遗传稳定性，是神经科学、肿瘤学和药物筛选研究中的重要模型系统。 T98G细胞的染色体数目超五倍体，通常在128至132条之间，且具有显著的染色体结构改变。 大部分细胞中存在14至16条标记染色体，这些标记染色体多为复杂的染色体间易位形成，如der (1)t (1;?) (p36;?)、i (6p)、der (10)t (10;?)。 其中，der (10)和der (19)标记染色体可能由平衡易位形成，即t (10;19) (q24;q13)，这些标记物以及微小稳心点在多数细 …

Morphology of T98 glioblastoma cells. (A) untreated cells (control group), cells treated with graphene oxide at concentration: 5 µg/mL (B), 100 µg/mL (C), and reduced graphene oxide at...

Polymorphic enzyme analysis of cultured human tumor cell lines. Human tumor lines for cancer research. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.