Q-band examination did not show the presence of a Y chromosome. This differentiated epithelial substrain (T-47D) was found to contain cytoplasmic junctions and receptors to 17 beta estradiol, other steroids and calcitonin. The cells express the WNT7B oncogene.

T-47D is a human breast cancer cell line commonly used in biomedical research involving the hormonal expression of cancer cells. [1] The cells were derived from the pleural effusion of a ductal carcinoma found in the mammary gland of an elderly human patient.

Establishment and characterization of a cell line of human breast carcinoma origin. Mutations in p53 as potential molecular markers for human breast cancer. Cell lines from human breast.

T47D-KBluc is an epithelial cell line that was isolated in 2000 from a pleural effusion of a 54-year-old, female patient with ductal carcinoma of the mammary gland. This cell line was deposited by VS Wilson and can be used in assay development and cancer research.

2017年5月6日 · Overall, the results highlight the importance of selecting appropriate cell lines for breast cancer studies and suggest that T47D cell lines can be an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancer.

2017年5月6日 · Although T47D and MCF-7 cell lines represent a luminal A subtype of breast cancer, our analysis suggests that the cell lines exhibit distinct molecular characteristics and that the T47D cell line is an ideal in vitro model for a progesterone-responsive luminal A …

STR analysis according to the global standard ANSI/ATCC ASN-0002.1-2021 (2021) resulted in an authentic STR profile of the reference STR database. Molec. Genetics:

The SN38-resistant T47D breast cancer cell sublines T47D/SN120 and T47D/SN150 were established after long-term exposure (more than 16 months) of wild-type T47D cells to 120 nM and 150 nM SN38, respectively.

Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 1 of 2: Normalized growth rate inhibition values.

2016年9月30日 · We demonstrate that androgens promote migration and invasion in T47D via Moesin activation. We show that T and DHEA exert their actions via the AR and estrogen receptor (ER), while the non-aromatizable androgen – DHT – only recruits AR.