2020年8月7日 · The T2609 phosphorylation cluster is one of the most prominent posttranslational modifications of DNA-PKcs and has been associated with increased radiation sensitivity (24, …

2020年9月15日 · Activated DNA-PK phosphorylates DNA-PKcs at the S2056 and T2609 clusters. Loss of T2609 cluster phosphorylation increases radiation sensitivity but whether T2609 …

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination. The DNA-dependent protein kinase (DNA-PK), …

2022年1月28日 · 内容提示： ICS 91. 100 . 10 ccs Q 13 JC 中华人民共和国建材行业标准JC /T 2609- 2021 聚合物水泥加固砂浆Polymer modified mortar for strengthening struc 伽 re2021 - …

Activated DNA-PK phosphorylates DNA-PKcs at the S2056 and T2609 clusters. Loss of T2609 cluster phos-phorylation increases radiation sensitivity but whether T2609 phosphorylation has …

Our results suggest that there is an additive or cumulative effect of DNA-PKcs phosphorylation within the T2609 cluster region. Increasing alanine replacement within the T2609 cluster …

2020年2月26日 · Blocking the phosphorylation of DNA-PKcs at the T2609 cluster, but not the S2056 cluster, led to KU-dependent defects in 18S rRNA processing, compromised global …

Our search reveals that IR-induced phosphorylation of T2609 in DNA-PKcs is a critical requirement for this interaction. Surprisingly, T2609 phosphorylation is also under the …

2020年4月24日 · DNA-PKcs is the best-characterized substrate of DNA-PK, which phosphorylates DNA-PKcs at both the S2056 and T2609 clusters. Loss of T2609 cluster …

The catalytic subunit of DNA dependent protein kinase (DNA-PKcs) and its kinase activity are critical for mediation of non-homologous end-joining (NHEJ) of DNA double-strand breaks …