T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state.

In this article we discuss T cell anergy, exhaustion, senescence, and stemness, and review the phenotype of dysfunctional T cell subsets and the underlying molecular mechanisms in the tumor microenvironments.

In this review, we discuss the phenotype, functionality, and the underlying mechanisms of anergic T cells, exhausted T cells, senescent T cells and stem-like T cells in the tumor microenvironment.

T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state.

2007年7月6日 · Understanding the state of long-lived functional unresponsiveness of T cells, known as T-cell anergy, could help to prevent T-cell-driven autoimmune diseases.

2009年6月15日 · In this review, I highlight a series of intracellular proteins in quiescent T cells that function to integrate signals from Ag, costimulatory, and growth factor receptors.

Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy. Keywords: anergy, NFAT, T helper cell, melanoma, immune evasion

2016年2月1日 · In this study, we found that anergy was selectively induced in fetal antigen–specific maternal CD4 + T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal...

Upon antigen removal, the cells recover their functionality while losing exhaustion and anergy markers. Our data suggest an adjustable response of CD4 + T cells to different levels of persisting antigen and contribute to a better understanding of chronic disease.

CD8 T cell activation and differentiation is tightly controlled, and dependent on the context in which naïve T cells encounter antigen, can either result in functional memory or T cell dysfunction, including exhaustion, tolerance, anergy, or senescence.