Sep 3, 2021 · 下图是3个典型的大颗粒t淋巴细胞白血病（t-lgll）病例，用于与t-cus进行对比，其特点是在骨髓（上、下）或外周血（中）标本有类似的克隆性cd8阳性t细胞群（红色事件），其trbc1呈阴性（上）、弱阳（中）或阳性（下）。

May 13, 2020 · In routine laboratory practice, T-cell clones of uncertain significance (T-CUS) were detected in 42 of 159 (26%) patients without T-cell malignancy, and in 3 of 24 (13%) healthy...

TCR-Vβ repertoire analysis confirmed the clonality of T-CUS, and identified additional clonotypic CD8-positive subsets when combined with TRBC1 analysis. We hereby report the phenotypic features and incidence of clonal T-cell subsets in patients with no demonstrable T-cell neoplasia, providing a framework for the differential interpretation of ...

Jul 1, 2023 · T-CUS shows immunophenotypic features closely resembling those of T-cell large granular lymphocytic leukaemia but the individuals are devoid of clinical or laboratory features, which would support a diagnosis of T-cell malignancy, in particular, bone marrow invasion, associated diseases, cytopenias, and related symptoms.

Jan 1, 2025 · T-cell clones of uncertain significance (T-CUS) exhibit molecular and immunophenotypic features closely resembling those of T-cell large granular lymphocytic leukemia (T-LGLL). However, individuals harboring these rogue clones lack any clinical or laboratory features supporting a diagnosis of a T-cell malignancy.1-3

Results: T-CUS was identified in 152 samples from 92 patients. The majority (76%) were CD8+ and demonstrated an immunophenotype resembling large granular lymphocytes. Eighteen patients had serial samples for longitudinal analysis (9.8 months median follow-up). Clone size was stable in 66%, whilst the remainder reduced or disappeared.

Jan 1, 2000 · T-CUS are a potential precursor of T-cell malignancies, mainly T-cell large granular lymphocytic leukaemia. The precise incidence of T-CUS is still being refined. Due to the availability of increasingly sensitive laboratory assays, it is envisaged that T-CUS will be more frequently intercepted.

Benign clonal T-cell expansions, however, are commonly found in patients without identifiable disease, a condition referred to as T-cell clones of uncertain significance (T-CUS). In practice, T-cell clonality testing is performed for a range of reasons and results are often challenging to interpret given the overlap between benign and malignant ...

Nov 17, 2022 · We compared the differential expression of 15 markers in PTCL (Peripheral T-cell lymphoma) subtypes and T-CUS (T-cell clones of uncertain significance), and summarized the specific immunophenotype profiles of each subtype and its impact on prognosis. PD-1 and CD10 are diagnostic markers for AITL (angioimmunoblastic T-cell lymphoma).

Nov 5, 2024 · Here, we describe the occurrence of T-cell clones of uncertain significance (T-CUS) in peripheral blood, tissue, and body fluids in patients with no documented evidence of T-cell malignancies. Methods: Expression of cell surface markers was measured using the ClearLLab 10C 10-color B-cell, T-cell, M1, and M2 panels on the Navios, Beckman ...