2025年3月30日 · SYT4 (Synaptotagmin 4) is a Protein Coding gene. Diseases associated with SYT4 include Pontocerebellar Hypoplasia, Type 2E and Pheochromocytoma. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT11.

"SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi: …

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in negative regulation of Catecholamine secretion and positive regulation of dendrite extension.

2009年5月17日 · Synaptotagmin-IV (syt-IV) is a membrane trafficking protein that influences learning and memory, but its localization and role in synaptic function remain unclear. We found that...

2011年2月10日 · Synaptotagmin-4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of synaptotagmin-4 and thus enhanced negative regulation of oxytocin release. Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obesogenic.

2024年2月1日 · In the present study, we discovered that synaptotagmin-4 (Syt4), an immediate-early gene 22 that modulates the interaction of neurotransmitter release, synaptic transmission, and Ca 2+ entry 23,...

Synaptotagmin-4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of syn-aptotagmin-4 and thus enhanced negative regulation of oxytocin release. Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obeso-genic.

Synaptotagmin-4 (SYT4) is a membrane protein that regulates membrane traffic in neurons in a calcium-dependent or calcium-independent manner. In melanocytes, the intracellular free calcium ion (Ca²⁺ ) may be important for dendrite growth and melanogenesis.

SYT4 is a member of the synaptotagmin family that serves as a postsynaptic calcium ion sensor to release retrograde signals that stimulate enhanced presynaptic function through activation of the cAMP-dependent protein kinase pathway (Yoshihara et al., 2005).

The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]