The SH-SY5Y cell line is a thrice cloned subline of the neuroblastoma cell line SK-N-SH (ATCC HTB-11), which was established in 1970 from a metastatic bone tumor from a 4-year-old cancer patient. Applications include use as a transfection host or in immunology, neuroscience, and toxicology research.

Transformed neuronal-like cell lines can be used in vitro to overcome this limitation. However, several caveats exist when utilizing cells derived from malignant tumors. In this context, the popular SH-SY5Y neuroblastoma cell line and its use in in vitro systems is described.

SH-SY5Y is a thrice-subcloned cell line derived from the SK-N-SH neuroblastoma cell line. It serves as a model for neurodegenerative disorders since the cells can be converted to various types of functional neurons by the addition of specific compounds.

The neuroblastoma cell line SH-SY5Y has been a well-established and very popular in vitro model in neuroscience for decades, especially focusing on neurodevelopmental disorders, such as Parkinson’s disease. The ability of this cell type to ...

2021年9月8日 · The SH-SY5Y cell line is a comparatively homogeneous neuroblast-like cell line, which exhibits neuronal marker enzyme activity (tyrosine and dopamine-β-hydroxylases), specific uptake of norepinephrine (NA), and expresses one or more neurofilament proteins. SH SY5Y cells also express opioid, muscarinic, and nerve growth factor receptors.

SH-SY5Y cells have been used to study the molecular and cellular mechanisms underlying the effects of some of the PD-related toxins, to perform functional studies on familial PD genes, and to test putative protective compounds for PD treatment.

The SH-SY5Y human neuroblastoma cell line (ATCC® CRL-2266™) is one of the most used cell lines in neurosciences, either undifferentiated or differentiated into neuron-like cells.

2024年2月27日 · In the quest to unravel the mysteries of neurological diseases, comprehending the underlying mechanisms is supreme. The SH-SY5Y human neuroblastoma cell line serves as a crucial tool in this...

人神经母细胞瘤细胞（sh-sy5y） 是于1970年建自骨瘤转移灶的神经母细胞瘤 sk-n-sh细胞系经3次克隆后的亚系(sk-n-sh→sh-sy→sh-sy5→sh-sy5y)。该细胞的密度可高达106 cells/cm2，具有中等水平的 多巴胺β羟化酶 的活性。

2025年2月11日 · Explore the unique features and growth phases of SH-SY5Y cells, focusing on their receptor expression and signal transduction pathways. SH-SY5Y cells, a human-derived neuroblastoma cell line, are widely used in scientific research due to their versatility and relevance to neurological studies.