2024年9月10日 · A loss of the dopaminergic neurons of the substantia nigra leads to Parkinson disease, and the symptoms of this disease can be treated using dopamine-supplementation approaches.

Restoring the lost physiological functions of the substantia nigra in Parkinson's disease (PD) is an important goal of PD therapy. The present article reviews a) novel drug targets that should be targeted to slow PD progression, and b) clinical and experimental research data …

2025年2月17日 · Parkinson disease (PD), also known as idiopathic Parkinson disease (iPD), is a neurodegenerative disease and movement disorder characterized by bradykinesia, rigidity and resting tremor due to progressive degeneration of dopaminergic neurons in the substantia nigra.

2023年8月7日 · The primary etiology appears to be the accumulation of alpha-synuclein in various parts of the brain, primarily the substantia nigra, leading to degeneration and subsequent loss of dopamine in the basal ganglia that control muscle tone and movement.

These findings have strengthened the link between the substantia nigra and Parkinson's disease, but modern research has uncovered the multifaceted nature of this neurodegenerative disorder by identifying other brain structures and chemospecifc systems involved in its pathogenesis.

2021年6月8日 · This review presents up-to-date imaging applications in the substantia nigra and its related structures used in Parkinson disease and other parkinsonian syndromes, assesses their usefulness, and discusses multimodal approaches that might further improve the diagnosis and treatment of this disease.

2025年3月5日 · Although many brain areas are affected in Parkinson’s disease, the most common symptoms result from the loss of neurons in an area near the base of the brain called the substantia nigra. The neurons in this area produce dopamine. Dopamine is the chemical messenger that transmits signals in the brain to produce smooth, purposeful movement.

These findings have strengthened the link between the substantia nigra and Parkinson's disease, but modern research has uncovered the multifaceted nature of this neurodegenerative disorder by identifying other brain structures and chemospecifc systems involved in its pathogenesis.

2025年2月13日 · Background: The substantia nigra (SN) and locus coeruleus (LC) are among the first brain regions to degenerate in Parkinson's disease (PD). This has important implications for early cognitive deficits because these nuclei are sources of ascending neuromodulators (i.e., dopamine and noradrenaline) that support various cognitive functions such as ...

Parkinson's disease significantly impacts the substantia nigra, a critical area of the brain involved in movement control. This region is part of the basal ganglia and is primarily responsible for producing dopamine, a neurotransmitter essential for …