2025年3月30日 · STX8 (Syntaxin 8) is a Protein Coding gene. Diseases associated with STX8 include Prostate Cancer and Ceroid Lipofuscinosis, Neuronal, 8. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics.

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. [5][6][7] Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. [8] . The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes. [9]

该基因是突触融合蛋白家族的成员。 编码的蛋白质通过囊泡融合和胞吐作用参与从早期到晚期内体的蛋白质运输。 已在 12 号染色体上鉴定出一个相关的假基因。 可变剪接导致多个转录本变体。 [RefSeq 提供，2010 年 5 月] The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12.

2024年12月27日 · 本文将详细介绍stx8基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一重要基因在细胞生物学中的作用。 stx8基因概述 stx8基因，也被称为carb，位于人类染色体17p13.1位置，编码一个蛋白质产品。

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3 (By similarity). Interacts with TPC1 (By similarity). Search… Showing features for coiled coil, domain.

STX8 silencing increased the levels of Hsp 60 a protein involving in early events in protein folding. Conclusion: STX8 knockdown creates an environment favorable for mature ΔF508 to reach the cell surface. The data also suggest that when present at normal levels, STX8 functions as part of the cell's quality control mechanism.

2016年4月21日 · CD107a脱颗粒，实时和终点人群细胞毒性测定以及高分辨率显微镜技术支持我们的结论，即Stx8是通过人CTL的内体途径正确，及时地将细胞毒性分子正确分类和运输至功能LG所必需的。

Syntaxin 8 (Stx8) is expressed in LG and colocalizes with the T cell receptor (TCR) upon IS formation. Here, we report the significance of Stx8 for human CTL cytotoxicity. We found that Stx8 mostly localized in late, recycling endosomal and lysosomal compartments with little expression in early endosomal compartments.

We have found that Stx8, a fungal SNARE similar to human syntaxin 8, is a retromer cargo, and have identified its retromer binding motif. Sequence screening and comparison has determined that this sorting motif is conserved mainly in fungal Stx8 sequences.

预测能实现几个功能，包括SNAP受体活性；氯通道抑制剂活性；和泛素蛋白连接酶结合活性。 参与内质网到溶酶体的运输和囊泡融合。 位于晚内质网膜和溶酶体膜上。 是SNARE复合体的一部分。 与人类的STX8（SNAP合成素8）有正则关系。 [由基因组资源联盟，2022年4月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Functional annotation of a full-length mouse cDNA …