Mar 30, 2025 · STAG2 (STAG2 Cohesin Complex Component) is a Protein Coding gene. Diseases associated with STAG2 include Mullegama-Klein-Martinez Syndrome and Holoprosencephaly 13, X-Linked. Among its related pathways are Separation of Sister Chromatids and Cell Cycle, Mitotic.

Apr 12, 2023 · The stromal antigen 2 (STAG2) gene, located on chromosome Xq25, is a core component of the cohesin complex that functions on chromatin organization, transcriptional regulation, and postreplicative DNA repair. 1-3STAG2 mutations (STAG2 ms) are reported in 5% to 10% of myeloid neoplasms (MNs), mostly high-risk myelodysplastic syndrome (MDS) and ac...

Nov 15, 2022 · Introduction: Stromal Antigen 2 (STAG2), located on chromosome Xq25, is the most mutated cohesin complex (CC) gene in myeloid neoplasms (MN), mostly MDS and AML. Somatic STAG2 mutations (STAG2 m) are described …

Dec 2, 2016 · INTRODUCTION: STAG2 is a component of the cohesin complex involved in the cohesion of sister chromatids, transcriptional regulation and DNA repair. Recent sequencing studies have identified cohesion mutations in myeloid malignancies with data suggesting a potential adverse impact on survival.

Stromal antigen 2 (STAG2) is a gene that codes for cohesin subunit SA-2,a subunit of the cohesin complex, which is involved in many cellular processes, such as DNA double-strand break repair and chromatid segregation during mitosis (PMID: 19886810).

Feb 9, 2025 · Title: STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia. STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.

Nov 29, 2024 · In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2...

Sep 5, 2019 · We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation.

Apr 16, 2018 · We uncover several uncharacterized cellular pathways and stromal antigen 2 (encoded by STAG2) that facilitate RV infection.

Aug 11, 2020 · STAG2 is commonly mutated in cancer, and germline mutations have been identified in cohesinopathy patients. To better understand the underlying pathogenic mechanisms, we report the consequences of Stag2 ablation in mice.