Mutations of STAG2 occur frequently in many cancers, which indicates this protein has a role in cancer. Mutations of the STAG2 gene are frequently seen in multiple adult and pediatric cancers. STAG has been found to be the only gene of 12 that is …

2024年12月25日 · STAG2 (STAG2 Cohesin Complex Component) is a Protein Coding gene. Diseases associated with STAG2 include Mullegama-Klein-Martinez Syndrome and Holoprosencephaly 13, X-Linked. Among its related pathways are Separation of Sister Chromatids and Cell Cycle, Mitotic.

2024年11月29日 · In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2...

2023年4月12日 · The stromal antigen 2 (STAG2) gene, located on chromosome Xq25, is a core component of the cohesin complex that functions on chromatin organization, transcriptional regulation, and postreplicative DNA repair. 1-3STAG2 mutations (STAG2 ms) are reported in 5% to 10% of myeloid neoplasms (MNs), mostly high-risk myelodysplastic syndrome (MDS) and ac...

stag2或其同源物stag1与由smc1a、smc3和rad21组成的三元环状结构相互作用，形成粘附素复合体的核心。stag2和stag1有很高的序列相似性，可以部分补偿彼此的功能。然而，stag2而不是stag1的突变在各种癌症中频繁发生…

2022年11月15日 · Introduction: Stromal Antigen 2 (STAG2), located on chromosome Xq25, is the most mutated cohesin complex (CC) gene in myeloid neoplasms (MN), mostly MDS and AML. Somatic STAG2 mutations (STAG2m) are described …

Stromal antigen 2 (STAG2), a subunit of the cohesin complex, is recurrently mutated in various tumors. However, the role of STAG2 in DNA repair and its therapeutic implications are largely unknown. Here it is reported that knockout of STAG2 results in increased double-stranded breaks (DSBs) and chro …

2022年4月6日 · Here we show that depletion of STAG2 in melanoma cells leads to expansion of topologically associating domains (TADs) and enhances the formation of acetylated histone H3 lysine 27...

该基因的靶向失活会导致染色单体内聚缺陷和非整倍体，这表明内聚蛋白的遗传破坏是人类癌症中非整倍体的一个原因。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2013 年 9 月] The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division.

2025年2月6日 · 作为黏连蛋白复合体的重要亚基，STAG2（STromal AntiGen 2）的生物学功能缺陷与肿瘤发生存在显著关联。 临床基因组学数据显示，STAG2在膀胱癌、骨髓增生异常综合征等多种恶性肿瘤中呈现高频突变特征。