2018年1月1日 · 课题组拟进一步通过临床标本、细胞与分子生物学实验和动物实验，研究阐述SPON1-WNT/β-catenin轴在胰腺癌及其免疫微环境中的作用机制，进而为胰腺癌的诊治提供新的思路。

2007年9月11日 · Here we provide a mechanism whereby RSpo1 regulates cellular responsiveness to Wnt ligands by modulating the cell-surface levels of the coreceptor LRP6. We show that RSpo1 activity critically depends on the presence of canonical Wnt ligands and LRP6.

除Wnt1 与Wnt3 后, 小鼠Rspo1在脊髓中的表达量显著减少. 该研究首次揭示了Rspo 与Wnt之间可能存在相互作用。 2004 年,Kazanskaya 等[11] 发现爪蟾Rspo2可以激活β-catenin 信号系统,进一步研究发现小鼠Rspo1~3 以及人Rspo2、Rspo3 furin-like 结构域后,Rspo 丧失与LRP6、Fzd 以及Wnt1 的结合作用;另 外Rspo 与LRP6以及Wnt1 可以协同激活β-catenin 信号,删除两个furin.

2007年9月11日 · Here we show that Rspo1 regulates Wnt signaling by modulating levels of LRP6 on the cell surface, through inhibition of DKK1-dependent internalization of LRP6. To further investigate the role of RSpo1 in the activation of the Wnt pathway, we generated a HEK-293 stable cell line expressing a TCF luciferase reporter plasmid.

2022年4月29日 · Combining bioinformatics assays and experimental signalling evidences, we found that SPON1 can enhance the IL‐6/JAK/STAT3 signalling. Mechanistically, SPON1 exerts its oncogenic roles in pancreatic cancer by maintaining IL‐6R trans‐signalling through stabilizing the interaction of soluble IL‐6R (sIL‐6R) and glycoprotein‐130 (gp130) in PDAC cells.

细胞外基质蛋白SPON1激活WNT/β-catenin信号通路促进胰腺癌侵袭转移和免疫逃逸的机制研究 负责人：霍砚淼 依托单位：上海交通大学 批准年份：2017

2016年12月15日 · Rspo1 is known to strongly promote proliferation of the Wnt-dependent intestinal-crypt stem cell compartment, 49,50 with this activity being primarily attributed to the Fu1 and Fu2 domains of this protein, 51 which are involved in direct physical interaction with the members of the leucine-rich repeat-containing G protein-coupled receptors 4 ...

2023年7月20日 · Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration.

【摘要】胰腺癌是起源于胰腺的恶性肿瘤,生存率极低,复发率极高,严重影响患者生命质量.胰腺癌较早出现转移,早期诊断较困难,化疗过程易出现化学耐药.Wnt信号通路与胰腺癌迁移,侵袭,转移有关.本文综述了Wnt信号通路及其与癌症及胰腺癌侵袭和转移的关系,以期 ...

2019年3月20日 · R-spondin 1 upregulation via genetic (overexpression) and pharmacological (recombinant protein) approaches facilitates growth and migration of normal ovarian cells. R-spondin 1 downregulation via siRNA knockdown decreases proliferation and migration, and induces apoptosis in ovarian cancer cells.