The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes (anaphase) until each chromosome is properly attached ...

2023年3月24日 · The spindle assembly checkpoint (SAC) ensures correct chromosome segregation during mitosis by inhibiting anaphase until all kinetochores are attached to microtubules.

2012年11月20日 · During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.

2022年9月22日 · Consequently, genome integrity is monitored by two major checkpoints, the DNA damage response (DDR) and the spindle assembly checkpoint (SAC). The DDR monitors DNA lesions in G1, S, and G2 stages of the cell cycle and the SAC ensures proper chromosome segregation in M phase.

The spindle checkpoint ensures proper chromosome segregation during cell division. Unraveling checkpoint signaling has been a longstanding challenge due to the complexity of the structures and forces that regulate chromosome segregation.

The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase onset before chromosomes have achieved bipolar attachment to the spindle.

2006年10月15日 · The spindle checkpoint is a surveillance mechanism that delays anaphase onset until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. FIG1. The core spindle checkpoint proteins are Mad1, Mad2, …

2002年10月1日 · The spindle checkpoint monitors the interactions between chromosomes and microtubules. The Mad and Bub proteins are core components of this cell-cycle control. The checkpoint can...

The spindle checkpoint detects unattached or tensionless kinetochores during mitosis and delays anaphase onset to ensure the fidelity of chromosome segregation. Recent progress on the molecular understanding of the spindle checkpoint is reviewed.

2015年10月19日 · The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle.