Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature.

Structure. Sphingolipids are amphipathic molecules; they have hydrophobic and hydrophilic properties. In the hydrophobic region there is a sphingoid long chain base (aliphatic chains with attached hydroxyl groups) with a fatty acid chain attached by amide bond at carbon 2.

2024年4月1日 · Sphingolipids are a diverse class of lipids that play important roles in cellular structure and signaling. They can be classified into two main categories: simple sphingolipids and complex sphingolipids. Simple sphingolipids are the early products of sphingolipid synthesis and include sphingoid bases and ceramides.

Sphingolipids are a second type of lipid found in cell membranes, particularly nerve cells and brain tissues. They do not contain glycerol, but retain the two alcohols with the middle position occupied by an amine. Sphingosine has three parts, a three carbon chain with two alcohols and amine attached and a long hydrocarbon chain.

In addition to being precursors for structural lipids, long-chain bases and ceramides are intra- and inter-cellular signalling molecules, especially in animal cells, while another relatively simple sphingolipid, sphingosine-1-phosphate, is now recognized as a factor in countless aspects of animal metabolism. The concentrations of these ...

Explore the diverse world of sphingolipids, their structural variations, and classification. Learn about powerful detection methods, including liquid chromatography-mass spectrometry (LC-MS), used to identify and quantify these vital lipid molecules in biological samples.

Sphingolipid, any member of a class of lipids (fat-soluble constituents of living cells) containing the organic aliphatic amino alcohol sphingosine or a substance structurally similar to it. Among the most simple sphingolipids are the ceramides (sphingosine plus a fatty acid), widely distributed in

All sphingolipids consist of sphingoid base (phytoceramide or sphinganine) linked to a fatty acid, and ceramide is the simplest one in structure (Fig. 1). Diverse sphingolipids result from different hydrophobic sphingoid bases combined with fatty acids; both vary in chain length and degrees of saturation and hydroxylation.

2023年10月21日 · This comprehensive guide offers an in-depth study into the structure, role and biosynthesis of sphingolipids, essential components within biological systems. You'll gain insights into sphingolipids' key elements, their involvement in organic chemistry, and the step-by-step process behind their biosynthesis.

Sphingolipids are complex molecules found in eukaryotic cell membranes that consist of sphingosine, phospholipids, and glycolipids. They have a polar head group and two hydrophobic tails, and are important components of lipid rafts. Sphingolipids have various functions, including acting as receptors for proteins and playing a role in inflammation.