The human gene SPAST codes for the microtubule -severing protein of the same name, commonly known as spastin. [5] This gene encodes a member of the AAA (ATPases …

Spastin is a microtubule severing ATPase and mutations in the gene encoding spastin cause axonal degeneration. N‐terminal spastin domains serve to recruit it to cellular sites of action. A …

2019年3月5日 · In addition to its ATP-dependent severing activity, spastin is an ATP-independent regulator of microtubule dynamics that slows shrinkage and increases rescue. We observed …

Spastin is a microtubule (MT)‑severing enzyme identified from mutations of hereditary spastic paraplegia in 1999 and extensive studies indicate its vital role in various cellular activities. In …

2025年3月30日 · SPAST (Spastin) is a Protein Coding gene. Diseases associated with SPAST include Spastic Paraplegia 4, Autosomal Dominant and Hereditary Spastic Paraplegia. Among …

2024年4月22日 · Spastin is a hexameric AAA-ATPase MT-severing enzyme that pulls tubulin heterodimers from the lattice 17, 18, 19 and is found neuronally enriched at axonal growth …

Here, we report the characterization of SPG4 (also known as SPAST), a gene encoding a new member of the AAA family, which is responsible for the most frequent form of AD-HSP. …

Spastin is a microtubule (MT)-severing enzyme identified from mutations of hereditary spastic paraplegia in 1999 and extensive studies indicate its vital role in various cellular activities. In …

2023年9月12日 · We found that 14-3-3 interacted with spastin by targeting the phosphorylation of Ser233, protecting spastin against ubiquitin-mediated degradation, thus up-regulated the …

2025年2月9日 · Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle …