2025年3月30日 · SP7 (Sp7 Transcription Factor) is a Protein Coding gene. Diseases associated with SP7 include Osteogenesis Imperfecta, Type Xii and Craniodiaphyseal Dysplasia. Among its related pathways are Gene expression (Transcription) and RUNX2 regulates bone development.

Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. [5] It is a member of the Sp family of zinc-finger transcription factors [5] It is highly conserved among bone-forming vertebrate species [6] [7] It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of ...

Ichazo called SP7 "Defenders", people who have a need to band with others who have similar interests [1], having a passion for inclusion that leads to relationships of mutual protection. [2] Naranjo called the preservative gluttons as people who want the good things life has to offer, starting with maternal love, warmth of family, money, sex ...

2023年3月7日 · SP7-associated signaling pathways, SP7-dependent target genes, and epigenetic regulations of SP7 serve as new therapeutic targets in the treatment of skeletal disorders. This review addresses the importance of SP7-regulated bone development in studying bone health and skeletal disease.

Sp7 转录因子： 该基因编码 Sp/XKLF 转录因子的 Sp 亚家族成员。 Sp 家族蛋白是序列特异性 DNA 结合蛋白，其特征在于氨基末端反式激活结构域和三个羧基末端锌指基序。

Its current official gene symbol is Sp7; it contains three C2H2-type zinc fingers—which have high homology with those in Sp family transcription factors Sp1, Sp3, and Sp4—at its C terminus. Based on the following observations, as well as the presence of C2H2-type zinc fingers, Sp7 was thought to have typical properties of TFs.

2025年2月8日 · The identification and initial characterization of the SP7 gene will facilitate the study of the molecular regulation of osteoblast differentiation in humans. Sp7 expression in humans is largely confined to osteoblasts and chondrocytes, both of which differentiate from the mesenchymal lineage.

本综述旨在概述 Sp7 在骨骼发育和维护中的作用，特别关注我们对 Sp7 在生理和病理条件下如何在骨骼中发挥作用的理解的最新进展。 Osteoblast differentiation is a tightly regulated process in which key transcription factors (TFs) and their target genes constitute gene regulatory networks (GRNs) under the control of osteogenic signaling pathways.

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs.

sp7相关信号通路、sp7依赖性靶基因和sp7的表观遗传调控成为骨骼疾病治疗的新治疗靶点。 概括 这篇综述探讨了 sp7 调节的骨骼发育在研究骨骼健康和骨骼疾病中的重要性。