Sox2 is one of the key transcription factors that play an essential role in maintaining pluripotency of stem cells. Sox2 interacts with Oct4 to form a binary complex, which then recruits other …

2025年3月30日 · SOX2 (SRY-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with SOX2 include Microphthalmia, Syndromic 3 and Septooptic Dysplasia. Among …

2019年9月2日 · Here we provide a comprehensive review of the current knowledge on SOX2 protein modifications, their proposed relationship to the PI3K/AKT pathway, and regulatory …

We place particular emphasis on the well-studied Sox2 protein with the goal of deriving general molecular and cellular principles by which Sox factors control stem and progenitor cell fates.

2020年7月29日 · In this review, we first briefly introduced SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. We …

2016年1月26日 · We compared SOX2 global binding profiles, SOX2-regulated genes and SOX2 protein interactome between hESCs and hNPCs, and performed functional assays to test …

2025年3月8日 · Title: SOX2 represses c-MYC transcription by altering the co-activator landscape of the c-MYC super-enhancer and promoter regions. Secreted factors from M1 macrophages …

The SOX2 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. Learn about this gene …

The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has become widely known because of its functional relevance for stem cells. In the developing nervous …

2020年7月30日 · SOX2 disorder, caused by an intragenic SOX2 pathogenic variant or a deletion of 3q26.33 involving SOX2 , is an autosomal dominant disorder. Approximately 60% of …