Sorbitol dehydrogenase - Wikipedia
Sorbitol dehydrogenase is an enzyme in carbohydrate metabolism converting sorbitol, the sugar alcohol form of glucose, into fructose. [2] . Together with aldose reductase, it provides a way for the body to produce fructose from glucose without using ATP.
Sorbitol dehydrogenase: structure, function and ligand design
Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. SDH is expressed almost ubiquitously in all mammalian tissues.
Biochemistry, Polyol Or Sorbitol Pathways - StatPearls - NCBI Bookshelf
2022年11月14日 · Additionally, sorbitol accumulation can impair kidney function due to the lack of sorbitol dehydrogenase. Studies have shown that sorbitol accumulation intracellularly leads to enzymuria and proximal tubular cell dysfunction. Sorbitol accumulation also impairs Schwann cell …
Sorbitol Dehydrogenase - an overview | ScienceDirect Topics
Sorbitol dehydrogenase (SDH) is present in several tissues where it catalyzes the reversible oxidation reduction of sorbitol, fructose, and NADPH (nicotinamide adenine dinucleotide phosphate). SDH is a sensitive and specific indicator of acute hepatocellular injury in rodents, dogs, and nonhuman primates and has been reported as valuable in ...
Sorbitol Dehydrogenase - ScienceDirect
1974年1月1日 · This chapter focuses on sorbitol dehydrogenase (SDH), which is classified with the polyol dehydrogenases. SDH has been demonstrated in various human, animal and plant tissues. Comparative studies have shown that SDH from Acetobacter suboxydans and from liver can be differentiated by their substrate specificity.
X-Ray Crystallographic and Kinetic Studies of Human Sorbitol Dehydrogenase
2003年3月19日 · Here, we present the first X-ray crystal structures of human sorbitol dehydrogenase (hSDH, E.C. 1.1.1.14), as well as hSDH plus its required cofactor, NAD +, and a ternary complex of hSDH, NADH, and a reversible active site inhibitor, CP-166,572.
Sorbitol Dehydrogenase: Structure, Function and Ligand Design
2004年3月1日 · Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose...
Sorbitol dehydrogenase - DrugBank Online
Polyol dehydrogenase that catalyzes the reversible NAD (+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415).
Sorbitol Dehydrogenase - ScienceDirect
This chapter examines the preparation and measurement of sorbitol dehydrogenase (SDH). SDH has been found in the liver and the genital organs of many mammals. In man the liver has the largest concentration of SDH, and the concentration of the enzyme in other organs is presented.
Sorbitol reduction via govorestat ameliorates synaptic …
Sorbitol dehydrogenase (SORD) deficiency has been identified as the most frequent autosomal recessive form of hereditary neuropathy. Loss of SORD causes high sorbitol levels in tissues due to the inability to convert sorbitol to fructose in the ...
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