SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC).

Trastuzumab emtansine 是一种抗体偶联药物 (ADC)，其结合了 HER2 靶向的 曲妥珠单抗 的抗肿瘤特性以及微管抑制剂 DM1 的细胞毒活性。可用于晚期乳腺癌的研究。

DM1-SMCC is a cleavable linker-based antibody-drug conjugate (ADC) containing the maytansinoid DM1 (mertansine; Item No. 22483) and the crosslinker SMCC. 1, 2 ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be …

2022年8月22日 · SMCC-DM1. 抗体偶联药物中间体。SMCC-DM1是由连接桥SMCC和DM1连接而成的,用来制备抗体偶联药物。 DM1(mertansine),是含硫醇的美登木素生物碱,是一种微管破坏剂。 Smcc-dm1**HCC1954和MDA-MB-468细胞增殖,ic50分别为17.2和49.9 nM 纯度：98%. SPDB-DM4. 产品名称：磺基SPDB-DM4. cas:1626359-59-8

DM1-SMCC (SMCC-DM1) 是一种 抗体药物偶联物 (ADC)-接头 (antibody drug conjugate (ADC)-linker)，由有效的微管破坏剂 DM1 和接头 SMCC 组成。

DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC. DM1 is an antibody-conjugatable maytansinoid which can overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1 binds at the tips of microtubules and suppresses the dynamicity of microtubules.

DM1-Smcc | C51H66ClN5O16S | CID 92131096 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC).