2024年12月25日 · SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Respiratory System Cancer and Lysinuric Protein Intolerance. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Blood-Brain Barrier: Anatomy.

2021年1月7日 · We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter,...

谷氨酰胺通过氨基酸转运蛋白 ASCT2/SLC1A5 进入细胞，并在线粒体中通过被谷氨酰胺酶 (GLS) 催化的脱氨反应转化为谷氨酸。 谷氨酸被谷氨酸脱氢酶 (GDH) 或丙氨酸或天冬氨酸转氨酶 (TAs) 转化为 TCA 循环中间物 α-酮戊二酸 (α-KG)。 此反应中，TAs 还会生成相应氨基酸。 α-KG 是一种关键的代谢物，可在 ATP 产生以及补充 TCA 循环中间物的过程（一种称为回补的过程）中发挥作用。 在缺氧或线粒体功能障碍期间，α-KG 在 IDH2 催化的还原性羧化反应中被转换为柠檬酸 …

2018年6月22日 · SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood br …

Distinct from glucose transporters, amino acid transporters include ones whose expression is specific to cancer cells. For example, LAT1 (SLC7A5) displays protein expression mostly limited to the plasma membrane of cancer cells.

We show that concomitant mutation of Apc and Kras in the mouse intestinal epithelium profoundly rewires metabolism, increasing glutamine consumption. Furthermore, SLC7A5, a glutamine antiporter, is critical for colorectal tumorigenesis in models of both early- …

关于 slc7a5 Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:87,830,023-87,869,507 (from NCBI) This gene has 3 transcripts (splice variants), 244 orthologues and 12 paralogues.

2021年3月22日 · Slc7a5是SLC家族成员之一，可以转运包括亮氨酸在内的大中性和支链氨基酸。 Slc7a5与Slc3a2形成异源二聚体，逆向转运氨基酸，从而共同承担氨基酸反转运蛋白的作用。

SLC7A5全称为溶质载体家族7成员5（Solute Carrier Family 7 Member 5），也被称为L型氨基酸转运蛋白1（LAT1）或CD98轻链。SLC7A5主要通过与SLC3A2（CD98重链）结合形成异源二聚体，负责转运细胞必需的中性氨基酸如亮氨酸、苯丙氨酸等，其活性与细胞增殖、代谢调控密切相关。

2025年1月28日 · We performed a metabolism-focused functional screen using CRISPR-Cas9 to identify pathways and factors that enable tumor growth in an arginine-depleted environment. Our screen identified the SLC-family transporter SLC7A5 as required for growth, and we hypothesized that this protein functions as a high-affinity citrulline transporter.