阳离子氨基酸转运蛋白 SLC7A1 (CAT1) 是 T 细胞重要的精氨酸转运蛋白， SLC7A2 (CAT2) 对先天免疫至关重要。 SLC 氨基酸转运蛋白与炎症和自身免疫之间的联系有助于更好地去了解疾病的潜在机制并提供新的潜在治疗途径。 图3. SLC1A1, SLC1A2和SLC1A3在CNS中的作用。 3. Amino Acid Solute Carrier...

2025年3月30日 · SLC7A1 (Solute Carrier Family 7 Member 1) is a Protein Coding gene. Diseases associated with SLC7A1 include Tinea Capitis and Trichothiodystrophy 2, Photosensitive. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Nanog in Mammalian ESC Pluripotency.

Enables L-arginine transmembrane transporter activity and L-histidine transmembrane transporter activity. Involved in amino acid transport. Located in membrane. Part of apical plasma membrane; basolateral plasma membrane; and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

2022年9月22日 · Cationic amino acid transporters (SLC7A1/CAT1) are highly expressed in human ovarian cancer (OC) tissues. However, the specific biological functions and mechanisms involved remain unclear. We used bioinformatics analysis to explore SLC7A1 expression ...

High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT. High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies.

溶质载体家族成员SLC7A11（Solute Carrier Family 7 Member 11，又名xCT）是溶质转运第7家族的第11个成员，属于 胱氨酸/谷氨酸逆向转运蛋白，主要参与氨基酸在质膜上的转运 [9, 10]。

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene. [5] [6]

2025年1月22日 · Single-cell analysis indicated that SLC7A1 was predominantly expressed in osteosarcoma cells and correlated with various malignant tumor characteristics. SLC7A1 also regulate interactions between tumor cells and macrophages, as well as modulate macrophage function through multiple pathways.

英文名： Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma. 杂志： Journal of Translational Medicine. 影响因子： 6.0/Q1. 发表时间： 2025年1月22日. 研究背景： 骨肉瘤是儿童和青少年最常见的恶性骨肿瘤，致残率和死亡率都很高。 在过去的三十年中，治疗效果一直不理想，这凸显了对创新治疗靶点的迫切需要。 溶质运载体（SLC）家族转运体与多种肿瘤的恶性进展有关，但它们在骨肉瘤中的具体作用仍鲜为人知。 …

2024年5月16日 · SLC7A1 was deposited in the HGSOC matrix, involved in TGF-β1-induced CAFs activation and CAFs phenotype acquisition, and promoted tumor cell progression. We also found that high expression of SLC7A1 in ovarian cancer …